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PRISM-LT

Financiado

PRInted Symbiotic Materials as a dynamic platform for Living Tissues production

The PRISM-LT aims at creating a flexible platform for next generation living tissue manufacturing based on Hybrid Living Materials. We plan to design a novel bio-ink where stem cells are integrated in a support matrix enriched w... ver más

31/10/2027

INsociety

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

IN SRL IMPRESA SOCIALE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 7 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-06-16

HORIZON-EIC-2021-PATHFINDERCHALLENGES-01-05: Engineered Living Materials Scope:Engineered living materials (ELMs) are composed, either entirely or partly, of living cells. E...

I+D

Cerrada hace 3 años

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7 Participantes

INsociety

479.06K€ | Lider

STICHTING RADBOUD UNIVERSITE...

449.50K€ | Participante

CELLINK BIOPRINTING AB

729.38K€ | Participante

UAveiro

449.09K€ | Participante

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Duración del proyecto: 64 meses Fecha Inicio: 2022-06-16
Fecha Fin: 2027-10-31

Líder del proyecto

IN SRL IMPRESA SOCIALE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Descripción del proyecto The PRISM-LT aims at creating a flexible platform for next generation living tissue manufacturing based on Hybrid Living Materials. We plan to design a novel bio-ink where stem cells are integrated in a support matrix enriched with engineered helper cells (either bacteria or yeasts, depending on the application and requirements). Tuning the operational parameters of the bioprinting process, we will cast down the material controlling the mechanical properties of each voxel, to get to a 3D patterned structure where stem cells are locally induced to initiate their differentiation towards different lineages. As far as stem cells proliferate, the helpers remain in a quiescent state. However, when the stem cells get stimulated by the local (printed) mechanics and enter a differentiation pathway, they start secreting a pool of lineage-specific metabolites. The helper cells are designed to sense these early markers of differentiation, and to respond by producing in-situ the corresponding growth factors, providing the relevant chemical guidance. Helper cells within the platform amplify the initial lineage commitment in each area and dynamically sustain differentiation on a longer term. During the project we will implement this strategy and develop two independent symbiotic materials, targeting biomedical and food applications, respectively.

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