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eprObes

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Preventing lifetime obesity by early risk factor identification prognosis and i...

Preventing lifetime obesity by early risk factor identification prognosis and intervention Obesity is one of the main population health threats worldwide, with a sustained increase in prevalence over the last decades and a constellation of co-morbidities that seriously hamper individual wellbeing and life-expectancy. De... ver más

30/04/2028

CENTRO DE INVESTIG...

10M€

Presupuesto del proyecto: 10M€

Líder del proyecto

CENTRO DE INVESTIGACION BIOMEDICA EN RED CIBE... Otra investigación y desarrollo experimental en ciencias naturales y técnicas asociacion

TRL 4-5 | 50K€

Fecha límite participación Sin fecha límite de participación.

Ver 22 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-04-11

HORIZON-HLTH-2022-STAYHLTH-01-05-two-stage: Prevention of obesity throughout th... ExpectedOutcome:This topic aims at supporting activities that are enabling or contributing to one or...

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No hay información privada compartida para este proyecto. Habla con el coordinador.

22 Participantes

CENTRO DE INVESTIGACION BIOM...

2.72M€ | Lider

UNIWERSYTET RZESZOWSKI

409.32K€ | Participante

AMARIS FRANCE SAS

N.D. | Participante

PREMIUM RESEARCH SL

490.81K€ | Participante

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Duración del proyecto: 60 meses Fecha Inicio: 2023-04-11
Fecha Fin: 2028-04-30

Líder del proyecto

CENTRO DE INVESTIGACION BIOMEDICA EN RED CIBE... Otra investigación y desarrollo experimental en ciencias naturales y técnicas asociacion

TRL 4-5 | 50K€

Presupuesto del proyecto 10M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Obesity is one of the main population health threats worldwide, with a sustained increase in prevalence over the last decades and a constellation of co-morbidities that seriously hamper individual wellbeing and life-expectancy. Despite major research efforts, obesity treatments have proven of limited efficacy. Thus, effective prevention strategies are essential to avoid the full spectrum of metabolic complications of overweight during the life-course. Adult obesity is rooted on early maturational events, including pathophysiological and psychological determinants occurring during the gestational, infantile and/or adolescent periods, which globally remain ill defined. Identification of such early pathogenic mechanisms and markers of metabolic disease is key for active prevention and personalized management of body weight disorders later in life. Of note, pathogenic mechanisms and susceptibility to obesity are seemingly gender-dependent, but this aspect remains underexplored and may compromise effectiveness of preventive measures and treatments tackling obesity and its complications. eprObes (for early Prevention of Obesity) is a multidisciplinary, patient-centered project, involving clinical studies targeting different maturational windows, coupled with cognitive, mental health, life-style and behavioral studies, as well as mechanistic analyses in suitable preclinical models, whose major aim is to define effective strategies for active prevention of obesity during the life-course, with particular focus on early developmental events, from prenatal (including peri-conceptional) to pubertal periods, and determinants of feeding behaviors. Multi-omics studies and integral analysis of eprObes data, assisted by bioinformatic technologies and artificial intelligence, will permit definition of tailored preventive measures and life-style interventions, at key maturational periods, to avoid excessive body weight gain and lifetime metabolic complications in both sexes.

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