Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

PRESERT

Financiado

PRESERT: linking prefrontal cortex, serotonin transporter and social cognition.

Neuropsychiatric and neurodevelopmental disorders are a heterogeneous group of mental diseases affecting about 1 billion people worldwide. Common alterations are in the cognitive and social domains, having a critical impact on the... ver más

31/03/2027

IIT

173K€

Presupuesto del proyecto: 173K€

Líder del proyecto

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-19

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023

I+D

Cerrada hace 1 año

0% 100%

1 Participantes

IIT

172.75K€ | Lider

Proyectos interesantes

SAF2009-08664 BASES NEUROBIOLOGICAS DE LA DEPRESION Y SU TRATAMIENTO. 133K€ Cerrado

CNS2023-143883 Enfermedades del sistema nervioso 200K€ Cerrado

PSI2008-00161 ESTUDIO DEL TRATAMIENTO CON UN AGONISTA SEROTONINERGICO DE A... 105K€ Cerrado

SAF2012-35183 PAPEL DE LA CORTEZA INFRALIMBICA EN DEPRESION: CONECTIVIDAD... 351K€ Cerrado

SAF2015-68346-P ALTERACIONES DE LA CORTEZA INFRALIMBICA EN DEPRESION: MECANI... 415K€ Cerrado

SAF2016-80726-R PAPEL DE LA SEROTONINA EN LAS TERAPIAS DE RECUPERACION COGNI... 182K€ Cerrado

Últimas noticias

27-11-2024: Videojuegos y creaci... Se abre la línea de ayuda pública: Ayudas para la promoción del sector del videojuego, del pódcast y otras formas de creación digital

27-11-2024: DGIPYME En las últimas 48 horas el Organismo DGIPYME ha otorgado 1 concesiones

27-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 2 concesiones

Duración del proyecto: 35 meses Fecha Inicio: 2024-04-19
Fecha Fin: 2027-03-31

Líder del proyecto

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

TRL 4-5

Presupuesto del proyecto 173K€

Descripción del proyecto Neuropsychiatric and neurodevelopmental disorders are a heterogeneous group of mental diseases affecting about 1 billion people worldwide. Common alterations are in the cognitive and social domains, having a critical impact on the public health, daily life, and long-term outcomes of affected patients. Unfortunately, efficient pharmacological interventions are still missing. The serotonin transporter (SERT) re-uptakes serotonin after synaptic release and is an important clinical target. SERT is widely expressed in the prefrontal cortex (PFC), an area profoundly engaged in socio-cognitive functions, and can be targeted by inhibitors -drugs acting by blocking the transporter- or by releasers- drugs acting as a substrate of SERT and then reversing its transport direction. The SERT releaser MDMA showed promising results for treating social dysfunctions in post-traumatic stress disorder and autism spectrum disorders and its pro-social effect seems dependent on SERT-reverse transport. Considering the efficacy of the SERT-releaser MDMA in modulating social dysfunctions, together with the need of SERT-reverse functions in mediating MDMA pro-social effects, and the role of the PFC in the regulation of socio-cognitive functions, the aim of PRESERT is to evaluate the impact of SERT on social cognition in mice. To achieve this overarching goal, PRESERT is divided into three specific objectives: i) investigating the impact of the PFC-expressed SERT on social cognition, ii) identifying the origin and connectivity of the underlying SERT-expressing circuits, and iii) evaluating if social cognition can be differentially modulated by the reverse transport (i.e. efflux) or the simple inhibition of SERT. As a direct consequence, PRESERT has the potential to link SERT, its molecular functions, and the underlying brain circuits to specific aspects of social cognition setting the ground for the development of innovative treatments for neuropsychiatric disorders.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores