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PRIMOGAIA

Financiado

Cerrado

Prepolarized MRI at Earth Field to seek new contrasts linked to molecular events...

Prepolarized MRI at Earth Field to seek new contrasts linked to molecular events for very early detection of pathologies PrimoGaia opens up a new pathway in Magnetic Resonance Imaging (MRI) by initiating the concept of in vivo enzymatic imaging for a better understanding of human physiology, early detection and prognosis of diseases, monitoring of t... ver más

30/11/2023

CNRS

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 8 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-11-30

FETOPEN-01-2018-2019-2020: FET-Open Challenging Current Thinki...

I+D

Cerrada hace 6 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

8 Participantes

CNRS

727.88K€ | Lider

UNITO

444.47K€ | Participante

STELAR

417.50K€ | Participante

UMONS

475.75K€ | Participante

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Duración del proyecto: 50 meses Fecha Inicio: 2019-09-04
Fecha Fin: 2023-11-30

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto PrimoGaia opens up a new pathway in Magnetic Resonance Imaging (MRI) by initiating the concept of in vivo enzymatic imaging for a better understanding of human physiology, early detection and prognosis of diseases, monitoring of therapeutic treatment. The main objective is to overcome current boundaries by making it possible to map and quantify the activity of an enzyme in a pathological tissue. It will be accomplished by building an MRI instrumentation operating at earth field in order to allow the use of 70MHz frequency for saturating the Electron Paramagnetic Resonance (EPR) transition of Nitroxyl radicals. Enzyme activity is assessed by the use of suitable probes designed to generate the radical upon action of the enzyme of interest. Upon saturation of the radical EPR resonance, polarization is transferred to the protons of the water molecules (Overhauser MRI). The enhancement factor will be high (more than two orders of magnitude). The polarized water signal thus reports on the local concentration of the radicals that reflect the enzymatic activity. 3 lines of activity will be addressed to generate the radicals of interest, namely: i) using a radical-containing molecular precursor that, upon the action of specific enzyme, yields a radical whose absorption frequency is sufficiently different to be selectively irradiated; ii) the use of paramagnetic impurities on nanodiamond surfaces to increase the OMRI effect; iii) the use of radical precursors as prodrugs generating a signal only after their activation. The overall methodology will be much less expensive than the current clinical scanners and will allow distribution in developping countries. PrimoGaia brings together an interdisciplinary consortium of research teams from 4 academics: Aix-Marseille University, U Mons, U Torino (reagents), CNRS Bordeaux (EPR unit, sequences, biology); Fraunhofer (Physics) and 2 companies: Stelar (magnetic unit) and Pure Devices an innovative SME (MRI instrumentation).

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