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PID2021-122930NB-I00

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PREDICIENDO LA EVOLUCION DE LOS FENOTIPOS COMPLEJOS MEDIANTE LA CONTRASTACION Y...

PREDICIENDO LA EVOLUCION DE LOS FENOTIPOS COMPLEJOS MEDIANTE LA CONTRASTACION Y LA COMBINACION DE LA GENETICA CUANTITATIVA Y EL MODELAJE MATEMATICO DEL DESARROLLO EMBRYONIC DEVELOPMENT INVOLVES GENE REGULATORY NETWORKS, EXTRACELLULAR SIGNALING, CELL BEHAVIORS (CELL DIVISION, ADHESION, ETC.) AND MECHANICAL INTERACTIONS. ONE FUNDAMENTAL QUESTION IN BIOLOGY IS HOW ARE ALL THESE THINGS COORDINA... ver más

01/01/2021

UAB

104K€

Presupuesto del proyecto: 104K€

Líder del proyecto

UNIVERSITAT AUTÒNOMA DE BARCELONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 1262

Financiación concedida El organismo AGENCIA ESTATAL DE INVESTIGACIÓN notifico la concesión del proyecto el día 2021-01-01

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UAB

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Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Líder del proyecto

UNIVERSITAT AUTÒNOMA DE BARCELONA

Total investigadores 1262

Presupuesto del proyecto 104K€

Descripción del proyecto EMBRYONIC DEVELOPMENT INVOLVES GENE REGULATORY NETWORKS, EXTRACELLULAR SIGNALING, CELL BEHAVIORS (CELL DIVISION, ADHESION, ETC.) AND MECHANICAL INTERACTIONS. ONE FUNDAMENTAL QUESTION IN BIOLOGY IS HOW ARE ALL THESE THINGS COORDINATED IN TIME AND SPACE TO LEAD TO THE CONSTRUCTION OF COMPLEX AND ROBUST MORPHOLOGIES? THIS QUESTION CAN BE ADDRESSED IN A SPECIFIC SYSTEM, E.G. IN THE HUMAN BODY OR A PART OF IT, OR IN GENERAL FOR THE ENSEMBLE OF ANIMALS AS: IS THERE ANY GENERAL REQUIREMENT THAT THE NETWORKS OF GENE AND CELL INTERACTIONS IN DEVELOPMENT NEED TO FULFILL TO LEAD TO COMPLEX ROBUST MORPHOLOGIES? FOR EXAMPLE, ARE THERE SOME GENE NETWORK TOPOLOGIES THAT TEND TO BE ASSOCIATED WITH MORPHOLOGICAL COMPLEXITY OR ROBUSTNESS? OR PERHAPS THERE SHOULD NOT BE TOO MUCH CELL DIVISION WITHOUT EXTENSIVE SIGNALING OR OTHERWISE MOLECULAR NOISE WOULD GET GREATLY AMPLIFIED? OR PERHAPS THERE IS SOME OTHER GENERAL REQUIREMENT THAT WE CAN NOT CURRENTLY EVEN CONCEIVE. TO ADDRESS THIS QUESTION THIS PROJECT ATTEMPTS THREE DIFFERENT APPROACHES. THEY ARE ALL BASED IN EMBRYOMAKER A COMPUTATIONAL MODEL OF EMBRYONIC DEVELOPMENT THAT CAN SIMULATE ANY DEVELOPMENTAL NETWORK (MARIN-RIERA ET AL. 2016): ANY GENE REGULATORY NETWORK AND THE CELL SIGNALING, CELL BEHAVIORS (CELL DIVISION, ADHESION, ETC.), MECHANICAL PROPERTIES AND MECHANICAL INTERACTIONS SUCH GENE NETWORK REGULATES. BY PROVIDING THE ADEQUATE DEVELOPMENTAL NETWORK AND INITIAL CONDITION (I.E. AN INITIAL SPATIAL DISTRIBUTION OF CELLS AND GENE EXPRESSION) EMBRYOMAKER COULD SIMULATE THE DEVELOPMENT OF ANY ORGANS AND BODY PARTS. THIS IS, IN OTHER WORDS, HOW THE SPATIAL DISTRIBUTION OF CELLS (I.E. MORPHOLOGY) AND GENE EXPRESSION CHANGE OVER DEVELOPMENTAL TIME. EMBRYOMAKER HAS BEEN USED TO SIMULATE THE DEVELOPMENT OF DIFFERENT ORGANS SUCH AS TEETH (MARIN-RIERA ET AL., 2018) AND SPIRAL CLEAVAGE (BRUN-USAN ET AL., 2017). IN THE FIRST APPROACH, THE ENSEMBLE APPROACH, WE WILL BUILD A HUGE NUMBER OF DEVELOPMENTAL NETWORKS BY WIRING GENE PRODUCTS, EXTRACELLULAR SIGNALS AND CELL BEHAVIORS AT RANDOM. WE WILL SIMULATE THEM WITH EMBRYOMAKER AND EXPLORE WHAT IS SHARED BY THE DEVELOPMENTAL NETWORKS THAT DEVELOP COMPLEX AND ROBUST MORPHOLOGIES. DEVELOPMENTAL NETWORKS ARE CERTAINLY NOT RANDOM, WE JUST BUILD THEM RANDOMLY AS A WAY TO EXPLORE THE SPACE OF THE POSSIBLE WITHOUT BIAS. IN THE EVOLUTIONARY APPROACH WE WILL COMBINE EMBRYOMAKER WITH A POPULATION GENETICS MODEL IN WHICH WE WILL HAVE A GENOTYPE, MUTATION, RECOMBINATION, A PHENOTYPE ARISING BY RUNNING EMBRYOMAKER OVER EACH INDIVIDUALS MORPHOLOGY AND NATURAL SELECTION ON THESE MORPHOLOGIES. WE WILL SELECT FOR DIFFERENT FORMS OF MORPHOLOGICAL COMPLEXITY AND ROBUSTNESS TO UNDERSTAND HOW DEVELOPMENTAL NETWORKS CAN EVOLVE TO PRODUCE COMPLEX ROBUST MORPHOLOGIES AND WHAT DO THEY NEED TO BE ABLE TO DO IT. IN THE LAST APPROACH WE WILL SIMPLY SIMULATE, WITH EMBRYOMAKER, THE DEVELOPMENTAL STAGES IN WHICH THERE ARE LONG-DISTANCE COMPLEX MORPHOGENETIC MOVEMENTS. THIS IS THE GASTRULATION IN THE MAJOR CHORDATE GROUPS: AMPHIOXUS, ZEBRA FISH, XENOPUS, THE NEWT, CHICKEN AND MOUSE. THIS MODELING SHOULD ALLOW US, IN ONE HAND, TO BETTER UNDERSTAND THE DYNAMICS AND LOGIC OF THIS CRUCIAL PROCESS AND, IN THE OTHER, UNDERSTAND SPECIFIC EXAMPLE SOF HOW A COMPLEX MORPHOLOGY CAN DEVELOP ROBUSTLY IN SPITE OF THE INTRINSIC NOISE OF THE MOLECULAR AND CELL LEVEL AND THE EXTENSIVE LONG-DISTANCE MOVEMENTS OF GASTRULATION. EDES GENETICAS\MAPA GENOTIPO-FENOTIPO\MORFOGENESIS\GASTRULACION\SELECCION NATURAL\MODELOS MATEMATICOS\EVOLUCION\DESARROLLO EMBRIONARIO

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