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PragmaTIL

financed

Pragmatic approach to Adoptive Cell Therapy (ACT) using Tumor Infiltrating Lymph...

Pragmatic approach to Adoptive Cell Therapy (ACT) using Tumor Infiltrating Lymphocytes (TIL) in selected solid tumors The PragmaTIL trial aims to optimize treatment of cancer patients with Tumour-Infiltrating Lymphocytes Adoptive Cell Therapy (TIL-ACT) and substantially expand and improve the clinical implementation of this treatment modality in... see more

31/03/2028

FUNDACIO PRIVADA I...

6M€

Project Budget: 6M€

Project leader

FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCO... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 16M€

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2023-04-28

HORIZON-MISS-2022-CANCER-01-03: Pragmatic clinical trials to optimi... Expected Outcome:While cancer research and innovation have generated novel treatment options, cancer...

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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14 Participantes

FUNDACIO PRIVADA INSTITUT D'...

1.10M€ | Leader

REGIONH

882.78K€ | participant

INSTITUT GUSTAVE ROUSSY

219.38K€ | participant

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Project duration: 59 months Date Start: 2023-04-28
End date: 2028-03-31

Project leader

FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCO... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 16M€

Project Budget 6M€

participation deadline Sin fecha límite de participación.

Project description The PragmaTIL trial aims to optimize treatment of cancer patients with Tumour-Infiltrating Lymphocytes Adoptive Cell Therapy (TIL-ACT) and substantially expand and improve the clinical implementation of this treatment modality in academic hospitals. To this end, treatment related toxicities, associated to high-dose interleukin 2 (HD-IL-2) required for expansion and activation of TILs will be reduced while maintaining efficacy. This improved tolerability will achieve a better clinical management of patients and enhance their quality of life, both of which represent major barriers for applying this treatment. The objectives of PragmaTIL are: i) To determine whether TIL-ACT using IL-2 analog ANV419 reduces the frequency of Grade 2-4 study-related non-hematological toxicities; ii) To compare the quality of life (QoL) of patients during their hospitalization period, using ANV419 vs HD-IL-2. Also, to compare short and long-term measurements of treatment-related toxicities and QoL co-defined by and for patients and their caregivers; and iii) To develop the health technology assessment (HTA) of TIL-ACT using ANV419, as well as a social return of investment (SROI) analysis. To achieve these objectives, the PragmaTIL project is structured into 6 WP that cover all the requirements to implement the project: WP1) Clinical Trial; WP2) IMPD Coordination, RA and Pharmacovigilance; WP3) Patients as co-researchers and Evaluation of Short- and Long-term PROs; WP4) Health Economics; WP5) SROI, Sustainability and Exploitation; WP6) Scientific Coordination, Project Management, Communication and Dissemination. The global impact of this project will not only reach patients, clinical and translational researchers and policy makers but may help to achieve a better acceptance of these therapies by society at large.

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