Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PeroxyZyme

Financiado

Practical oxyfunctionalisation biocatalysts by engineering monooxygenases into p...

Practical oxyfunctionalisation biocatalysts by engineering monooxygenases into peroxyzymes. Chemistry is far away from being a mature science: many desirable transformations are still out of scope. One important example is the selective (oxy)functionalisation of non-activated C-H bonds, which still represents a dream rea... ver más

31/07/2027

TU Delft

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

TECHNISCHE UNIVERSITEIT DELFT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-06-01

ERC-2021-ADG: ERC ADVANCED GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

TU Delft

2.50M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

CCBioCat Biocatalytic C-C bond formation by repurposing transaminases 188K€ Cerrado

UPOxArene Unspecific Peroxygenases for the Oxidation of Arenes 188K€ Cerrado

RTI2018-094637-B-I00 CATALIZADORES HIBRIDOS ORGANOENZIMATICOS 121K€ Cerrado

PGC2018-101737-B-I00 CATALISIS DE OXIDACION BIOINSPIRADA MEDIANTE DISEÑO RACIONAL... 242K€ Cerrado

CTQ2017-82988-R PEROXIGENASAS COMO BIOCATALIZADORES PARA OXIGENACIONES REGIO... 163K€ Cerrado

RTI2018-094482-J-I00 SINTESIS BIOCATALITICA DE OLIGOFLAVONOIDES HIDROXILADOS 169K€ Cerrado

Duración del proyecto: 61 meses Fecha Inicio: 2022-06-01
Fecha Fin: 2027-07-31

Líder del proyecto

TECHNISCHE UNIVERSITEIT DELFT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Descripción del proyecto Chemistry is far away from being a mature science: many desirable transformations are still out of scope. One important example is the selective (oxy)functionalisation of non-activated C-H bonds, which still represents a dream reaction of organic chemistry. This is because balancing high reactivity (needed for the activation of inert C-H bonds) with selectivity is difficult to achieve. Enzymes, specifically monooxygenases, are catalysts that principally solve this challenge. Monooxygenases, however, are not practical catalysts for organic chemistry. This is because they have evolved to enable the survival of their host organisms and not to suit the needs of organic chemists. In particular the complex molecular architecture of monooxygenases (necessitating O2, stoichiometric reductants and additional catalytic components) together with mechanistic challenges arising from their complex molecular architecture impede their chemistry-wide application. PeroxyZyme aims at solving these issues and establish evolved monooxygenases (peroxyzymes) as practical catalysts for organic chemistry. Peroxyzymes will be able to function with simple hydrogen peroxide rather than via the natural, albeit complex and vulnerable electron transport chains. This fundamental change in the monooxygenases’ catalytic mechanisms will be achieved by a mechanism-driven and experimentally validated semi-rational engineering approach. Evolved peroxyzymes will be characterised using up-to date (ultra)fast spectroscopy identifying catalytic bottlenecks and possible inactivation mechanisms. This molecular understanding will provide the basis for further improvement of first generation peroxyzymes. The practical usefulness of evolved peroxyzymes will be demonstrated on preparative-scale by using them in non-aqueous reaction media enabling high product concentrations and space-time yields.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores