Innovating Works

PROMISE

Financiado
Portal Range Monitoring in Mixed Ion Beam Surgery
Half of the approximately 4 million annual cancer cases in Europe receive radiotherapy. While many cancer patients have benefitted from technical improvements in recent years, widespread diseases, such as pancreatic and lung cance... Half of the approximately 4 million annual cancer cases in Europe receive radiotherapy. While many cancer patients have benefitted from technical improvements in recent years, widespread diseases, such as pancreatic and lung cancer, still have dismally low cure rates, with median survival of less than 2 years. Carbon ion radiotherapy (CIRT) offers unprecedented precision in delivering tumour dose, and can be the much needed game changer for these patients. However, CIRT is vulnerable to uncertainties in patient positioning, anatomy changes and organ motion. The current clinical approach is to increase the high dose volume to ensure target coverage, counteracting the primary advantage of CIRT. Novel strategies for image guidance and beam range assessment are crucial to unlock the full potential of CIRT for the best possible patient care. PROMISE, for the first time, will produce mixed ion beams that enable concurrent treatment and image guidance. Carbon ions deliver the dose to the target while Helium ions, simultaneously accelerated to the same velocity, traverse the patient and monitor tumour location and beam range. PROMISE realizes true portal imaging, providing real-time information on the target anatomy as seen by the treatment beam. Coupled with innovative detectors, AI-based image recognition, and online dose reconstruction, this technique will enable to drastically reduce safety margins, and achieve the full potential of CIRT. The GSI accelerators are uniquely suited to develop the first mixed beam of Carbon and Helium, along with strategies for their cost-effective translation to existing and future clinical CIRT centres. The method will be validated experimentally in GSI’s former CIRT treatment room. Patient simulation studies will highlight clinical benefit and characterize ideal use cases. A demonstration in an animal model will pave the way for clinical transition. The mixed beam image guidance of PROMISE will lead to a paradigm shift in CIRT. ver más
28/02/2029
GSI
2M€
Perfil tecnológico estimado
Duración del proyecto: 60 meses Fecha Inicio: 2024-02-23
Fecha Fin: 2029-02-28

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-02-23
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2023-COG: ERC CONSOLIDATOR GRANTS
Cerrada hace 1 año
Presupuesto El presupuesto total del proyecto asciende a 2M€
Líder del proyecto
GSI HELMHOLTZZENTRUM FUR SCHWERIONENFORSCHUNG... No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5