Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PolyMAE

Financiado

Cerrado

Polymeric Membranes for Artificial Endosymbionts

Synthetic biology has constantly been expanding its reach, aiming to develop whole genetic circuits and metabolic pathways, which require laborious genetic engineering. Often, such pathways derive from other organisms and must be... ver más

03/05/2023

TECHNISCHE UNIVERS...

179K€

Presupuesto del proyecto: 179K€

Líder del proyecto

TECHNISCHE UNIVERSITAT DARMSTADT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-05-03

MSCA-IF-2020: Individual Fellowships

I+D

Cerrada hace 4 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

TECHNISCHE UNIVERSITAT DARMS...

109.19K€ | Lider

UNIVERSITY OF STRATHCLYDE

70.12K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

ARTISYM Artificial endosymbiosis 3M€ Cerrado

SYMBIOSES Novel Symbioses 3M€ Cerrado

SYNSEMBL Cell-free synthesis and assembly of biomolecular condensates... 2M€ Cerrado

BFU2015-64322-C2-1-R BIOLOGIA SINTETICA Y DE SISTEMAS DE ENDO Y EXOSIMBIONTES PAR... 188K€ Cerrado

Monopoly Baeyer Villiger Monooxygenases as Biocatalytic Parts for Mon... 225K€ Cerrado

SYNTOMAGX A synthetic biology approach for magnetization of foreign or... 2M€ Cerrado

Duración del proyecto: 25 meses Fecha Inicio: 2021-03-16
Fecha Fin: 2023-05-03

Líder del proyecto

TECHNISCHE UNIVERSITAT DARMSTADT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 179K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Synthetic biology has constantly been expanding its reach, aiming to develop whole genetic circuits and metabolic pathways, which require laborious genetic engineering. Often, such pathways derive from other organisms and must be tweaked to fit the host’s molecular biology, adding to the complexity of the task. However, nature has already witnessed the integration of whole prokaryotic organisms into eukaryotic hosts, where they are integrated as endosymbionts creating new combinations that live with mutual benefit. In evolutionary history, this phenomenon was at the origin of organelles such as mitochondria and chloroplasts, which added their own metabolism to their hosts. To achieve a more generalized framework, where any prokaryote can enter endosymbiosis with any eukaryote, we need to induce the uptake and retention of the guest by the eukaryotic host. A way forward will be by masking the guests with biocompatible polymers, either pre-formed, or synthesized by the bacterium itself. The project proposed herein offers a novel technique for the the encapsulation of prokaryotes into biocompatible shells, creating a new strategy for the straightforward production of bio-orthogonal, artificial endosymbionts. After the formation of the polymer shell around bacteria, they will be endocytoted by eukaryotes, thus expanding the biochemical potentialities of cells, revolutionizing the possibilities of synthetic biology, acting as true artificial organelles. This breakthrough will allow the functional insertion whole genomes into the host cells and the combination of micro-organisms, which will have implications in medicinal, industrial and environmental biotechnology. It will lead to the creation of complex, semi-synthetic hybrid organisms able to perform a vast variety of non-natural biotransformations. In line with the 2020 Work Programme, it will open up several diverse possibilities that will benefit European and global industries.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores