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SUPREME

Financiado

Polymeric Cyclodextrin-Based Supramolecular Constructs Photoreleasing Nitric Oxi...

Polymeric Cyclodextrin-Based Supramolecular Constructs Photoreleasing Nitric Oxide for Combating Antibiotic Resistance With more than 13 million people dying per year from infectious diseases Multidrug Resistance (MDR) in bacteria remains the greatest challenge in public health care. This scenario, associated to the low turnover of new clinically... ver más

31/07/2024

UNICT

173K€

Presupuesto del proyecto: 173K€

Líder del proyecto

UNIVERSITA DEGLI STUDI DI CATANIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 3 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-07-31

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

I+D

Cerrada hace 3 años

0% 100% 100%

3 Participantes

UNICT

172.75K€ | Lider

CYCLOLAB CYCLODEXTRIN R&D LA...

N.D. | Participante

UNIME

N.D. | Participante

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Duración del proyecto: 24 meses Fecha Inicio: 2022-07-22
Fecha Fin: 2024-07-31

Líder del proyecto

UNIVERSITA DEGLI STUDI DI CATANIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 173K€

Descripción del proyecto With more than 13 million people dying per year from infectious diseases Multidrug Resistance (MDR) in bacteria remains the greatest challenge in public health care. This scenario, associated to the low turnover of new clinically approved antibiotic drugs makes the development of innovative therapeutic approaches to fight antibiotic resistance desperately needed to address this devastating societal problem. In this frame, SUPREME aims at the implementation of a novel strategy based on unprecedented supramolecular platforms based on new cyclodextrin polymers integrating light-activatable nitric oxide (NO) photodonors (NOPD), alone and in combination with antibiotics currently employed in the clinic. The final goal is to exploit the double role of NO generated with superb spatiotemporal control thanks to the light triggering, as: i) bactericidal species not suffering MDR when produced at high doses (micro molar); ii) inhibitor of the efflux pumps mainly responsible for MDR, when produced at low doses, to revert antibiotic resistance. Highly biocompatible branched polymers containing mixed (alpha, beta and gamma) cyclodextrin units will be used as suitable hosts able to self-assemble into nanoparticles or gels encapsulating the therapeutic cargo with high efficiency. We will focus on NOPDs activatable exclusively with the biocompatible visible light and on antibiotics representative of the classes of fluoroquinolones and tetracyclines, known to display resistance and severe side effects. Full chemico-physical and photochemical characterization of the systems is planned as well as assessment of their efficacy against planktonic microbial cells and biofilms. The complementary expertise of the researcher and the supervisor supported by the private and academic teams hosting the fellow during secondments will create a multidisciplinary environment where all participants will benefit from reciprocal transfer of knowledge.

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