Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PASSAGE

Financiado

Plasmodium liver stage schizogony: high replication and genetic diversity

A world free of malaria is certainly a desirable goal. However, in spite of the significant incidence reduction achieved globally between 2000-2015, malaria still kills a child every minute. The limited understanding of Plasmodium... ver más

31/05/2028

iMM

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANT... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-05-31

ERC-2022-ADG: ERC ADVANCED GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

1 Participantes

iMM

2.47M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PoEMM Plasmodium Exploitation of Liver-specific Methionine Metabol... 173K€ Cerrado

BES-2016-076276 Epigenetics of Plasmodium-Anopheles interactions Cerrado

DEXES Mechanisms of dormancy, activation and sexual conversion in... 2M€ Cerrado

SAF2015-72117-EXP ANALISIS DEL POSIBLE PAPEL DE LA EPIGENETICA EN LA DETERMINA... 54K€ Cerrado

ReMVeC How has the rapid scale up of malaria control in Africa impa... 1M€ Cerrado

SAF2009-07760 APROXIMACIONES MOLECULARES PARA EL ESTUDIO DE VIRULENCIA EN... 235K€ Cerrado

Duración del proyecto: 60 meses Fecha Inicio: 2023-05-31
Fecha Fin: 2028-05-31

Líder del proyecto

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANT... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto A world free of malaria is certainly a desirable goal. However, in spite of the significant incidence reduction achieved globally between 2000-2015, malaria still kills a child every minute. The limited understanding of Plasmodium’s biology hampers the development of novel intervention strategies. Upon transmission by Anopheles mosquitos, Plasmodium parasites must reach the liver and infect hepatocytes. Inside a hepatocyte, each parasite replicates into thousands of new erythrocyte-infectious forms, which lead to disease. The parasite biomass generated during the liver stage (LS) of infection is directly associated with malaria severity, but how the parasite achieves such a high replication rate, and the consequences of that, remain utterly unexplored. Notably, Plasmodium replication is unusual. The parasite divides by schizogony, with divisions occurring without cytokinesis and it cannot salvage pyrimidines from the environment, relying solely on nucleotides synthesized de novo. Using a Plasmodium transgenic line specifically designed to study DNA replication throughout parasite development, I unveiled for the first time the temporal dynamics of DNA replication throughout parasite LS and show that Plasmodium’s LS high replication rate is accompanied by DNA damage. Thus, I hypothesize that DNA damage accumulation during LS schizogony is a generator of genetic variability prior to intra-erythrocytic infection. By using a combination of molecular, cell biology and genetic approaches, I now propose to characterize the mechanisms, define the molecular players, and reveal the causes and consequences of such a high replication rate in the outcome of infection and progression of disease, by exposing the consequences for parasite genetic diversity and virulence. Connecting LS schizogony with parasite genetic diversity and virulence for the first time will be conceptually transformative, and will certainly provide valuable targets and tools for the combat against malaria.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores