Innovating Works

PEST-BIN

Financiado
Pioneering Strategies Against Bacterial Infections
The World Health Organisation named antibiotic resistance as one of the greatest threats to global health, predicting the advent of infections not responding to antibiotics. The humanity needs to pioneer disruptive technologies to... The World Health Organisation named antibiotic resistance as one of the greatest threats to global health, predicting the advent of infections not responding to antibiotics. The humanity needs to pioneer disruptive technologies to re-gain the upper hand. To do so, PEST-BIN mobilized 5 universities, 3 institutes, a hospital and 5 private companies. We will fight infections with very diverse tools: from nano-engineering, antibiotic production, via proteomics-based diagnostics to big data analysis using artificial intelligence (AI). PEST-BIN will train ESRs in an interdisciplinary and intersectoral environment in these impact areas: 1) Diagnostics: Current diagnostic tools fail to meet the clinical requirements for high speed, throughput, accuracy, cost and simplicity of use. PEST-BIN will develop infection diagnostic kits based on graphene, that will be functionalized by receptors capturing infection biomarkers. Our chips will contain only pure carbon and biodegradable polymers – zero environmental footprint. They will be used as plug-and-play disposable chips with a micro-SD jack. 2) Infection mechanisms: MS proteomics has been extensively used to analyse infectious bacteria, but our understanding of infection mechanisms has not advanced much. PEST-BIN is taking two new directions: i) generate proteomics datasets more relevant, comprehensive and time-resolved and ii) use novel computational tools (based on AI) to analyse proteomics datasets. This will lead to new drug targets for development of antibiotics. 3) Killing biofilms: Dense extracellular matrix prevents drugs from reaching bacteria inside biofilms. This limited exposure enhances development of antibiotic tolerance. PEST-BIN will engineer magnetic nanoparticles (directed by magnetic field), spiked with antibacterial graphene coating which will be loaded with antibiotics. Such molecular nano-weapons will physically penetrate biofilms and ensure sustained delivery of antibiotics inside biofilms. ver más
31/12/2024
TECHNICAL UNIVERSI...
4M€
Duración del proyecto: 52 meses Fecha Inicio: 2020-08-28
Fecha Fin: 2024-12-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2020-08-28
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
MSCA-ITN-2020: Innovative Training Networks
Cerrada hace 4 años
Presupuesto El presupuesto total del proyecto asciende a 4M€
Líder del proyecto
DANMARKS TEKNISKE UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5