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Physical Activity Inflammation and Respiratory health an integrative analysis...

Physical Activity Inflammation and Respiratory health an integrative analysis of biological behavioural and environmental determinants The link between physical activity with respiratory health and chronic obstructive pulmonary disease (COPD) remains weak and under-investigated. The limited existing research seems to suggest that systemic inflammation could lie i... ver más

28/02/2018

FUNDACION PRIVADA...

170K€

Presupuesto del proyecto: 170K€

Líder del proyecto

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL B... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 27M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2018-02-28

MSCA-IF-2015-EF: Marie Skłodowska-Curie Individual F...

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Cerrada hace 9 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

FUNDACION PRIVADA INSTITUTO...

170.12K€ | Lider

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Duración del proyecto: 24 meses Fecha Inicio: 2016-02-15
Fecha Fin: 2018-02-28

Líder del proyecto

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL B... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 27M€

Presupuesto del proyecto 170K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The link between physical activity with respiratory health and chronic obstructive pulmonary disease (COPD) remains weak and under-investigated. The limited existing research seems to suggest that systemic inflammation could lie in the causal pathway of this relationship, and that inflammatory-related conditions may modify this potential causal mechanism, although these hypotheses remain largely understudied. This project will investigate 1) the effect of physical activity on lung function decline and COPD incidence in European adults, as well as 2) the mediating role of systemic inflammation and 3) the influence of biological (BMI, co-existing chronic inflammatory diseases), behavioural (diet, smoking) and environmental (air pollution, greenness, ultraviolet radiation) factors on this relationship. Data from over 18,000 subjects from 3 large population-based adult cohorts (ECHRS, SAPALDIA and NFBC), for which data on lung function and physical activity were prospectively collected during at least two follow-ups approximately a decade apart, will be included. Lung function was measured by spirometry according to international standards. Physical activity frequency, duration and type was collected using self-reported (ECRHS and NFBC) or interviewer-administered (SAPALDIA) questionnaires. Systemic inflammation will be assessed using C-reactive protein and interleukin-6 levels in serum. Data on the inflammation-related factors of interest were collected by the cohorts or derived from previous/ongoing collaborations. Cross-sectional and longitudinal associations, and potential interactive effects, will be examined by centre/cohort and combined estimates will be derived. Given that lung function is an important determinant of health and that physical activity is one of a very few prevalent individually-modifiable risk factors, the results of the proposed research have the potential for wide-spread implications as well as public health and economic impacts.

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