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BIOnanoPDT

Financiado

Cerrado

Phthalocyanine biopolymeric nanoparticle delivery systems for cancer photodynami...

Phthalocyanine biopolymeric nanoparticle delivery systems for cancer photodynamic therapy According to the World Health Organization cancer was responsible for approximated 9.6 million deaths in 2018 what is the reason of being one of the biggest civilizational health problem, just behind the heart diseases. The global... ver más

01/11/2022

CMPIW PAN

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

CENTRUM MATERIALOW POLIMEROWYCH IWEGLOWYCH PO... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-11-01

WF-02-2019: Widening Fellowships

I+D

Cerrada hace 5 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

CMPIW PAN

149.63K€ | Lider

SUMINISTROS CERAMICOS E INDU...

256.98K€ | Participante

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Duración del proyecto: 30 meses Fecha Inicio: 2020-04-15
Fecha Fin: 2022-11-01

Líder del proyecto

CENTRUM MATERIALOW POLIMEROWYCH IWEGLOWYCH PO... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto According to the World Health Organization cancer was responsible for approximated 9.6 million deaths in 2018 what is the reason of being one of the biggest civilizational health problem, just behind the heart diseases. The global objective of interdisciplinary BIOnanoPDT project is to develop novel biodegradable phthalocyanine (Pc)-polymeric nanoparticles (NPs) which enhance cancer photodynamic therapy (PDT). Up to now, there is no ideal therapy for cancer treatment but among the others PDT presents several advantages, e.g. it is a selective treatment with less secondary effects than other therapies. This promising therapy combines three components: photosensitizer (PS), light and oxygen. 20 years ago PDT was approved by Food and Drug Admnistration as a clinical protocol for cancer treatment but it still have limitations to use it in all types of cancer. The development of new powerful PSs, which specifically target cancer cells, and can more deeply penetrate tissue allowing to treat large tumors is still a challenge. Phthalocyanines (Pcs) are one of the most promising second generation PSs and meet many requirements for being ideal PSs. Unfortunately, very often Pcs are hydrophobic species and undergo self-aggregation in aqueous solutions, which drastically reduces their photosensitizing efficiency. In BIOnanoPDT project the limitations of Pcs will be overcame by tailoring their properties in terms of singlet oxygen generation and by incorporating them with polymer NPs which could improve their photophysical properties, selectivity for targeted tissues by surface modification, eliminate aggregation of the PSs and their low water solubility. Additionally, it can enhance the treatment by increasing the blood circulation and selective accumulation in tumor cells. The BIOnanoPDT project will bring many innovations to the current cancer research by novel Pc-polymer NP hybrids for cancer PDT which will be an attractive alternative for conventional drugs.

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