Molecules are the fundamental building blocks of life: disease is intrinsically linked to molecular malfunction and, sometimes, a tiny molecular error in a single cell can kill an organism. Drugs, such as antibiotics, are designed...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
ImagingRedox
Molecular imaging of redox processes in cancer
100K€
Cerrado
BIOSPEC
BIOphotonic SPECialists for Novel Raman Spectrometer Develop...
95K€
Cerrado
VIBRA
Very fast Imaging by Broadband coherent RAman
2M€
Cerrado
uCAIR
ULTRA-FAST CHEMICAL ANALYSIS IMAGING WITH RAMAN
Cerrado
Información proyecto PIRO
Duración del proyecto: 64 meses
Fecha Inicio: 2022-12-21
Fecha Fin: 2028-04-30
Líder del proyecto
STICHTING VU
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Presupuesto del proyecto
2M€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Molecules are the fundamental building blocks of life: disease is intrinsically linked to molecular malfunction and, sometimes, a tiny molecular error in a single cell can kill an organism. Drugs, such as antibiotics, are designed to protect us: they rid us of pathogens by disrupting their molecular machinery. If unsuccessful, surviving bacteria might adapt to evade future attacks and a few resistant bacteria can cause great damage.
Everything mentioned above relies on specific molecular changes. A technique that could rapidly visualise them holds great promise: it would allow us to specifically target this one deadly cancer cell or adopt antibiotics treatment before resistance emerges. Vibrational imaging, which combines spatial cues with molecular resolution, is the prime-candidate for revealing this molecular stand-off:
Spontaneous Raman readily acquires broadband spectra but is too slow to interrogate large samples. Coherent Raman can measure them but lacks spectral resolution. Finally, Fourier transform infrared microscopy combines spectral resolution and speed but its spatial resolution is insufficient.
PIRO promises to deliver the necessary tool for the job by combining concepts from nonlinear ultrafast spectroscopy and digital holography. PIRO implements a novel vibrational imaging platform: a phototransient infrared holographic microscope (PIROscope). The PIROscope, inspired by our recently introduced ultrafast holographic microscope, combines femtosecond IR-excitation with visible readout to, ultimately, retrieve spectrally resolved quantitative images with an unprecedented combination of imaging speed, spectral observation window and spatial-resolution.
During PIRO we will implement the PIROscope and validate it for biomedical imaging. We will then use our edge over the state-of-the-art to take first steps towards PIRO-based diagnostics by high-resolution visualising breast cancer tissue and the metabolic activity of antibiotics-treated bacteria.