Innovating Works

MultiCat-Metathesis

Financiado
Photoredox catalytic metathesis of TT-salts and aryl bromide/chloride via multic...
Sulfonium salts emerge as unique synthetic intermediates in recent years. Versatile exciting transformations have been developed since the breakthrough works by Procter’s and Ritter’s group. Progress made within just 4 years since... Sulfonium salts emerge as unique synthetic intermediates in recent years. Versatile exciting transformations have been developed since the breakthrough works by Procter’s and Ritter’s group. Progress made within just 4 years since thesee seminal works showcased their broad utilities surpassing that of organic halides. Depending on the conditions, sulfonium salts engaged in various types of transformations such as Suzuki coupling, Sonogashira coupling, Negishi coupling, Heck reaction, carbonylation, boronation, chlorination, iodination, cyanation, photocatalysis, etc., and realize the constructions of various C-C, C-N, C-O, C-X and C-S bonds. Therefore, they are considered Skeleton Key in Late state Functionalization thanks to excellent compatibility. However, compared with organic halides that widely exist in nature and are commercially available, the synthetic methods for thiananthenium salts are still very limited. Currently, the direct C-H activation is the rare method showing efficiency for constructing aryl thianthranium salts. Although this synthetic method showed a remarkable advantage in exquisite remote regioselectivity, it also uncovered a challenge in making other sulfonium salts with other substitution patterns impossibly, such as on ortho- and meta-positions. Herein I propose to explore the potential of preparing synthetically omnipotent diversative aryl thianthranium (TT) salts from available aryl halides via functional group metathesis. Attractively, the method will overcome the current limitation to the para-derivatives of TT-salts, giving access to any substitution pattern of TT-salts (ortho-, meta-, para-, bissubstituted, etc.). The target TT-salts will open up a vast realm of transformations and construction of useful skeletons in fine chemical synthesis and development. ver más
31/08/2026
196K€
Duración del proyecto: 37 meses Fecha Inicio: 2023-07-20
Fecha Fin: 2026-08-31

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-07-20
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
Presupuesto El presupuesto total del proyecto asciende a 196K€
Líder del proyecto
UNIVERSITE DE STRASBOURG No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5