MaxImmun
Financiado
Pharmaco-modulation of epithelia for induction of antimicrobial peptide expressi...
Pharmaco-modulation of epithelia for induction of antimicrobial peptide expression: a disruptive approach to fight antibiotic resistance
The MaxImmun project aims at preventing and treating infections, and situations of conflict between the host and its microbiota, by developing a disruptive technology based on molecules that boost antimicrobial peptides (AMP) of t...
The MaxImmun project aims at preventing and treating infections, and situations of conflict between the host and its microbiota, by developing a disruptive technology based on molecules that boost antimicrobial peptides (AMP) of the innate immune system. To face the problem of antibiotic resistance, this high-potential technology may be relevant both in situations of endemic infections in the developing world, and infectious or inflammatory pathologies in industrialized countries. Our objective is to establish the proof-of-concept that among a series of hit molecules identified for their capacity to promote AMPs, a small subgroup may qualify to lead molecules that can then be pushed into the late phases of the R&D pipeline, with the perspective of a phase I clinical trial. To achieve this transition, our project will range from the comprehension of microbial mechanisms leading to antibiotic resistance, to the comprehension of AMP regulations, the identification of molecules and their optimization by medicinal chemistry, and the characterization and evaluation of their protective efficacy in pre-clinical validation models. Thus, we expect to develop innovative molecules as future antimicrobial drug candidates.
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Duración del proyecto: 47 meses
Fecha Inicio: 2024-01-01
Fecha Fin: 2027-12-31
Fecha Fin: 2027-12-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-01-01
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-EIC-2023-PATHFINDEROPEN-01-01:
EIC Pathfinder Open
Cerrada
hace 1 año
Presupuesto
El presupuesto total del proyecto asciende a
3M€
Líder del proyecto
ECOLE NORMALE SUPERIEURE
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5