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OvaCTool

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Personalized medicine in ovarian cancer: Design and development of a tool for re...

Personalized medicine in ovarian cancer: Design and development of a tool for response prediction to targeted platinated nanocarrier-based treatments Personalized treatments are considered major challenges in clinical practice. They become particularly critical for diseases with poor prognoses diagnosed at later stages, such as ovarian cancer. Here, the vague symptoms, the lack... see more

15/01/2026

UNIOVI

181K€

Project Budget: 181K€

Project leader

Universidad de Oviedo No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 792

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2023-04-21

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 Expected Outcome:

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIOVI

181.15K€ | Leader

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Project duration: 32 months Date Start: 2023-04-21
End date: 2026-01-15

Project leader

Universidad de Oviedo No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 792

Project Budget 181K€

participation deadline Sin fecha límite de participación.

Project description Personalized treatments are considered major challenges in clinical practice. They become particularly critical for diseases with poor prognoses diagnosed at later stages, such as ovarian cancer. Here, the vague symptoms, the lack of reliable screening tools and the treatment resistances have made this cancer the most lethal gynaecological malignancy (40% 5-year survival rate; 50-90% recurrence rate). Thus, ovarian cancer patients would certainly benefit from improved therapies and appropriate treatment choices. In this regard, the present OvaCTool project aims at developing a highly sensitive mass cytometer-based tool for the prediction of treatment response against newly designed targeted nanocarriers for platinum (Pt)-based chemotherapy in ovarian cancer. Specifically, diverse iron-based nanocarriers for Pt (IV) prodrugs targeting ovarian cancer cells will be evaluated. Such assessment will also include the understanding of ovarian cancer proteome changes after therapy. All this information will then be integrated to define biomarkers of treatment response which will be combined in a mass cytometry panel (up to 50 markers) together with proteins to identify other cells from the tumour microenvironment aiming at the stratification of patients into responders vs non-responders to the newly designed drugs. Likewise, protein corona formation on the nanostructures will be investigated to recognize potential challenges after intravenous injection of the drug in the clinical setting. In summary, this project will provide potential enhanced anticancer drugs and a prediction tool for targeted treatment choices which will help towards better survival rates for this malignant disease.

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