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Personalised Risk assessment in febrile illness to Optimise Real life Management...

Personalised Risk assessment in febrile illness to Optimise Real life Management across the European Union The management of febrile patients is one of the most common and important problems facing healthcare providers. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable, and as a resu... see more

30/06/2021

IMPERIAL COLLEGE O...

18M€

Project Budget: 18M€

Project leader

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Ver 20 Participantes

Financing granted El organismo H2020 notifico la concesión del proyecto The day 2021-06-30

PHC-24-2015: Piloting personalised medicine in h... Scope:Specificchallenge:Personalised medicine[1] has the potential to respond to, amongst others, th...

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

20 Participantes

IMPERIAL COLLEGE OF SCIENCE...

5.37M€ | Leader

TELEVES

672.93K€ | participant

Academisch Medisch Centrum A...

746.45K€ | participant

LSHTM

1.67M€ | participant

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Project duration: 66 months Date Start: 2015-12-01
End date: 2021-06-30

Project leader

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 18M€

participation deadline Sin fecha límite de participación.

Project description The management of febrile patients is one of the most common and important problems facing healthcare providers. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable, and as a result innumerable patients worldwide undergo hospitalization, invasive investigation and are treated with antibiotics for presumed bacterial infection when, in fact, they are suffering from self-resolving viral infection. We aim to improve diagnosis and management of febrile patients, by application of sophisticated phenotypic, transcriptomic (genomic, proteomic) and bioinformatic approaches to well characterised large-scale, multi-national patient cohorts already recruited with EU funding. We will identify, and validate promising new discriminators of bacterial and viral infection including transcriptomic and clinical phenotypic markers. The most accurate markers distinguishing bacterial and viral infection will be evaluated in prospective cohorts of patients reflecting the different health care settings across European countries. By linking sophisticated new genomic and proteomic approaches to careful clinical phenotyping, and building on pilot data from our previous studies we will develop a comprehensive management plan for febrile patients which can be rolled out in healthcare systems across Europe.

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