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FUSIMO

financed

Patient specific modelling and simulation of focused ultrasound in moving organs

In recent years, High-Intensity Focused Ultrasound and Focused Ultrasound (FUS) have become frequent tools for non-invasive benign tumour therapy. Applications in the treatment of fibroadenoma of uterus has become commercial and p... see more

31/03/2014

Fraunhofer

5M€

Project Budget: 5M€

Project leader

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANG... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo FP7 notifico la concesión del proyecto The day 2014-03-31 We do not have the information of the call

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10 Participantes

Fraunhofer

0.00€ | Leader

ETH Zürich

N.D. | participant

UNIROMA1

N.D. | participant

TU Delft

N.D. | participant

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Project leader

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANG... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 5M€

participation deadline Sin fecha límite de participación.

Project description In recent years, High-Intensity Focused Ultrasound and Focused Ultrasound (FUS) have become frequent tools for non-invasive benign tumour therapy. Applications in the treatment of fibroadenoma of uterus has become commercial and passed FDA clearance in 2004 and sonication of bone metastasis has obtained a CE mark. Other tumours are under preclinical (prostate, kidney) and clinical (breast, brain and liver) evaluation. However, treating tumours with focused ultrasound is still challenging in terms of reliable therapy planning, monitoring and outcome prediction especially in moving organs with a complex blood supply. It is important to understand that the processes involved in FUS therapy are multi-level ranging from organ morphology, perfusion and motion, down to microscopic and cellular level. The relation within and between these levels is not well understood.FUSIMO will develop, implement and validate a multi-level model for moving abdominal organs for use with FUS and Magnetic resonance-guided focused ultrasound surgery. The overall model will consist of several sub-models, which interact and describe aspects in a hierarchical manner. The integrated model will consist of;- Abdominal organ model to simulate motion and the influence on ultrasound application- Target organ/tumour model to capture organ/tumour physiology, and organ/tumour reaction to therapy- Microscopic tissue model to simulate direct heat ablation, model energy distribution, tissue heating and cooling- Model to evaluate first steps to simulate drug delivery, microbubble distribution and dynamicsThe FUSIMO developments in the field of hardware and software will be combined into an integrated system, which will allow both abdominal FUS application to moving organs, and also other treatment modalities such as radio frequency, laser or cryotherapy or other types of interventions based on particles or fields in radiation therapy.

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