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Host4Hypnozoites

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Parasite-host interactions regulating dormancy and reactivation of malaria paras...

Parasite-host interactions regulating dormancy and reactivation of malaria parasites What? Hypnozoites are dormant liver stage malaria parasites that can reactivate and cause repeated blood-stage infections without the bite of an infectious mosquito. We will, for the first time: - characterize the cellular envir... ver más

28/02/2030

STICHTING RADBOUD...

13M€

Presupuesto del proyecto: 13M€

Líder del proyecto

STICHTING RADBOUD UNIVERSITEIT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-02-20

ERC-2023-SyG: ERC Synergy Grants Objective:The aim is to provide support for a small group of two to four Principal Investigators to...

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Cerrada hace 2 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

STICHTING RADBOUD UNIVERSITE...

3.70M€ | Lider

BPRC

5.80M€ | Participante

STICHTING AMSTERDAM UMC

1.93M€ | Participante

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Duración del proyecto: 72 meses Fecha Inicio: 2024-02-20
Fecha Fin: 2030-02-28

Líder del proyecto

STICHTING RADBOUD UNIVERSITEIT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 13M€

Descripción del proyecto What? Hypnozoites are dormant liver stage malaria parasites that can reactivate and cause repeated blood-stage infections without the bite of an infectious mosquito. We will, for the first time: - characterize the cellular environment contributing to dormancy at systems level (WP1) - explore the reactivation kinetic and tissue environment of hypnozoites within the natural host (WP2) - functionally characterize host & parasite factors governing dormancy or reactivation (WP3) Why? - Dormancy and reactivation of hypnozoites is an unresolved biological mystery since decades - Dormant parasites are a major obstacle to the curative treatment of malaria The challenge: Tracking the in vivo development and understanding the biology of these rare, quiescent parasites that normally reside inside the liver of the host The solution: A synergistic, multidisciplinary investigation, which is only possible if we combine the unique resources and complementary expertise of three leading laboratories in: - Radiopharmaceutical chemistry for the development of dedicated Positron Emission Tomography tracers for non-invasive investigation of the parasites in situ, as well as to capture infected tissue samples for systems level investigations - Systems biology for simultaneous multi-omics profiling of the parasite and the host cell at single-cell resolution and in the spatial context to be validated by parasitological assays - Parasitology for functional investigation through genetic engineering and manipulation of the parasites in vitro and validation within the natural host Anticipated project outcomes: - Detailed insights into the relapse characteristics of the parasite in vivo - Understanding how host and parasite factors collectively determine the fate of infection - Novel imaging, transfection and omics methods for malaria research and beyond - Opportunities for novel therapeutic strategies for awakening and killing these vicious pathogens

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