Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

GENINVADE

Financiado

Cerrado

Parasite population genomics and functional studies towards development of a blo...

Parasite population genomics and functional studies towards development of a blood stage malaria vaccine An effective malaria vaccine is needed, particularly against P. falciparum as this species causes more human mortality than all other eukaryotic pathogens combined. An understanding of natural selection operating on parasites in l... ver más

30/06/2017

LSHTM

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICIN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 8 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2017-06-30 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

8 Participantes

LSHTM

0.00€ | Lider

NC3Rs

N.D. | Participante

UNIVERSITY OF GHANA

UNIVERSITE DES SCIENCES DES...

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

MALMASQ Understanding immune evasion by malaria parasites 2M€ Cerrado

SAF2010-20111 BASES MOLECULARES DE LA REGULACION EPIGENETICA DE LA EXPRESI... 116K€ Cerrado

MALGENEXPRESSION The role of a nuclear expression site in the regulation of v... 100K€ Cerrado

PLASMOESCAPE Monoallelic Gene Expression in Malaria Parasites A Key Mech... 2M€ Cerrado

MALSWITCH Uncovering the Mechanisms Behind Adaptive Gene Expression Sw... 1M€ Cerrado

FIGHTMAL Correlating protection against malaria with serum profiles a... 2M€ Cerrado

Líder del proyecto

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICIN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto An effective malaria vaccine is needed, particularly against P. falciparum as this species causes more human mortality than all other eukaryotic pathogens combined. An understanding of natural selection operating on parasites in local endemic populations can enable understanding of core molecular mechanisms of global relevance. The objectives are to - Advance understanding of alternative pathways of erythrocyte invasion by malaria parasites - Advance understanding of immune evasion by malaria parasites - Identify optimal combinations of parasite proteins as malaria vaccine candidates - Develop the interface between population genomic and functional studies of malaria parasites The research programme will take an integrated approach to understanding pathogen adaptation, by designing experiments that are based on analysis at the molecular, functional, and population levels. (i) Population genetic analyses of P. falciparum in sites of contrasting endemicity in West Africa, to finely determine signatures of selection with high-resolution throughout the genome, and help refine hypotheses on mechanisms used by merozoites to invade erythrocytes and evade acquired immune responses. (ii) Experimental culture analysis of merozoite invasion into erythrocytes to identify the receptor-ligand interactions used by different parasite populations ex vivo. Novel receptor knockdown assays on cultured erythrocytes will be employed, and parasite adaptation experiments conducted to identify constraints on the use of alternative invasion pathways (iii) Innovative approaches to select individual parasites and characterise cell tropism, transcript profiles, and genome sequences. This is aimed to validate population level findings and revolutionise approaches to genetics and phenotyping of parasites in the future. Candidate molecule discoveries will be taken forwards to receptor-ligand interaction assays, antibody inhibition and immuno-epidemiological studies.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores