Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PALVIREVOL

Financiado

Cerrado

Paleovirology the evolutionary dynamics of viral cross species transmissions a...

Paleovirology the evolutionary dynamics of viral cross species transmissions and the consequences of virus host gene exchange Viruses are ubiquitous, obligate intracellular parasites that have had a pervasive influence on the evolutionary history of life. Despite being extensively studied due to their role in disease, very little is known about their lon... ver más

30/09/2026

UOXF

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-03-30

ERC-2020-COG: ERC CONSOLIDATOR GRANTS

I+D

Cerrada hace 5 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UOXF

2.00M€ | Lider

ALHENA INGENIERIA, COOPERATI...

Proyectos interesantes

CGL2016-76273-P

Medical Technol...

Data Science

303K€ Cerrado

CGL2010-17384

Medical Technol...

Data Science

97K€ Cerrado

C THE LIGER

Medical Technol...

Data Science

209K€ Cerrado

RNAVIRSPE

Medical Technol...

Data Science

217K€ Cerrado

RYC-2014-15373

Medical Technol...

Data Science

309K€ Cerrado

BFU2015-65037-P

Medical Technol...

Data Science

379K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 66 meses Fecha Inicio: 2021-03-30
Fecha Fin: 2026-09-30

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Viruses are ubiquitous, obligate intracellular parasites that have had a pervasive influence on the evolutionary history of life. Despite being extensively studied due to their role in disease, very little is known about their long-term evolution, since they do not form a geological fossil record. The new field of paleovirology is the study of ancient viruses, which in the genomic age has been facilitated by discoveries of endogenous viral elements (EVEs). EVEs are the remnants of viruses that have heritably integrated into the genomes of their hosts and we were the first to discover that viruses of all genome types can endogenise. This genomic fossil record contains information about viral/host interactions that would be impossible to recover from contemporary viral sequences. We will develop novel methodologies to exploit this data source in order to quantify how viral transmission dynamics vary between organisms and over time, and to identify the factors that determine this. While most EVEs are non-functional relics, they are sometimes captured and repurposed by their hosts to serve a beneficial function as antiviral genes. These remarkable examples indicate an important role for virus to host gene flow in evolution, and we will determine the nature and extent of this phenomenon. This gene exchange is mirrored in viruses that capture host genes to evade immune responses. We will integrate bioinformatics, evolutionary, and experimental techniques, to elucidate the evolutionary processes underlying virus-host gene flow in both directions, and to determine the molecular features that impact host immunity and viral pathogenicity. Now is the time to pursue this research, given the unprecedented availability of genomic data and the emergence of paleovirology. Our results will greatly improve our understanding of viral cross-species transmission, as well as the role of gene flow on the evolutionary arms race between viruses and their hosts over geological timescales.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores