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PATHOGEN

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Paleogenomic Analysis of Tuberculosis epidemiological Histories Over Geo-cultura...

Paleogenomic Analysis of Tuberculosis epidemiological Histories Over Geo-cultural and Ecological Networks in South America Tuberculosis (TB), the infectious disease produced by the Mycobacterium tuberculosis complex (MTBC), remains one of the highest global disease burdens. However, the current body of knowledge on the MTBC is biased towards certain l... ver más

30/04/2025

212K€

Presupuesto del proyecto: 212K€

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-22

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

I+D

Cerrada hace 2 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

211.75K€ | Lider

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Duración del proyecto: 25 meses Fecha Inicio: 2023-03-22
Fecha Fin: 2025-04-30

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 212K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Tuberculosis (TB), the infectious disease produced by the Mycobacterium tuberculosis complex (MTBC), remains one of the highest global disease burdens. However, the current body of knowledge on the MTBC is biased towards certain lineages, particularly lineage 4 that spread from Europe to the Americas during colonial expansion. Recent advances in ancient DNA research have the potential to broaden this picture with the recovery and analysis of whole genomes from strains that infected human populations in the past. Indeed, these approaches have been recently used to identify ancient MTBC animal associated strains infecting humans in South American before the arrival of Europeans. Analysis of these strains estimated that the MTBC most likely emerged during the Neolithic approximately 6000 years ago (much later than previously thought). The PATHOGEN project, will seek to use these approaches to shed new light on the emergence, diversity and spread of MTBC strains in the Southern Cone of the Americas, a neglected region concerning the epidemiological history of TB. By employing ancient DNA methods to examine and screen putatively positive TB infections of humans from archaeological and historic contexts of the current territory of Argentina, I will potentially provide genomic representation of TB histories over a broad time transect from precolonial populations to post-colonial cemeteries. With these data, I will perform phylogenomic and molecular clock analyses to investigate i) changes in strain diversity over time in the region, ii) the historical and socio-economical contexts that favoured the emergence and spread of the detected strains, iii) the emergence of genetic changes with potential clinical relevance identified in MTBC strains over the past centuries. By offering a view of the past, the PATHOGEN project will increase our understanding of the diversity of MTBC across time and contribute a new perspective of the evolutionary and epidemiological histories of TB.

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