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BACKWARD

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Overcoming the frontiers of biomolecular studies on human history and adaptation...

Overcoming the frontiers of biomolecular studies on human history and adaptation using palaeoproteomics BACKWARD will address major unsettled debates about African and Asian extinct hominid phylogeny, by developing and deploying a new generation of palaeoproteomic workflows, relying on the most advanced mass spectrometry and bioinfo... see more

31/12/2026

UCPH

2M€

Project Budget: 2M€

Project leader

KOBENHAVNS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo H2020 notifico la concesión del proyecto The day 2021-08-13

ERC-2020-ADG: ERC ADVANCED GRANT Specific Challenge:Objectives

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UCPH

2.50M€ | Leader

EUROKEYTON

208.25K€ | participant

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Project duration: 64 months Date Start: 2021-08-13
End date: 2026-12-31

Project leader

KOBENHAVNS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 2M€

participation deadline Sin fecha límite de participación.

Project description BACKWARD will address major unsettled debates about African and Asian extinct hominid phylogeny, by developing and deploying a new generation of palaeoproteomic workflows, relying on the most advanced mass spectrometry and bioinformatic solutions currently available. Ancient DNA (aDNA) sequencing revolutionised our knowledge on evolution, migration and admixture of archaic and anatomically modern humans. However, no hominid aDNA older than ~0.4 million years has been retrieved yet. Ancient proteins instead survive much longer than aDNA, enabling molecular-based phylogeny beyond the limits of aDNA degradation. Recently, mass spectrometry (MS)-based ancient protein sequencing, i.e. palaeoproteomics, convincingly demonstrated its transformative value, enabling molecular-based evolutionary reconstructions for species that went extinct millions of years ago. BACKWARD will use palaeoproteomics to address: (i) the phylogenetic relationships among South African early hominins, and (ii) the hominid palaeobiodiversity in Southeast Asia; two topics debated for generations, and further complicated by recent finds. This knowledge will also provide the evolutionary scaffolding needed to correctly identify and correlate the series of processes that defined human brain expansion and reorganization. BACKWARD will also screen large sets of morphologically non-informative isolated fossil fragments of bones and teeth, to identify the species and sex of the organism from which they originated. Some of these solutions will be commercially re-purposed to deliver superior performance in public and private analytic laboratories for diagnostics in forensic medicine, and in the food or pharmaceutical industry. As a key BACKWARD feature, the unique contribution provided by each participating institution will be integrated in a strong partnership to transform palaeoanthropology, palaeontology, palaeoecology and archaeology once again, as aDNA did over the last twenty years.

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