Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

OBSERVE

Financiado

Cerrado

Overcoming cellular barriers to therapeutic RNA delivery using extracellular ves...

Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles RNA-based therapeutics, including siRNA, miRNA, mRNA and CRISPR/Cas9 components, have unprecedented therapeutic potential and hold the promise of treating any disease with a genetic component. However, inefficient delivery into di... ver más

31/01/2025

UMC UTRECHT

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITAIR MEDISCH CENTRUM UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2025-01-31

ERC-2019-STG: ERC Starting Grant

I+D

Cerrada hace 6 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UMC UTRECHT

1.50M€ | Lider

EMILIO ESTEBAN

334.27K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

UNRAVEL Unravelling extracellular vesicle heterogeneity to inspire i... 2M€ Cerrado

TraffikGene-Tx TraffikGene-Tx: Targeted Peptide Carriers for RNA Delivery 2M€ Cerrado

grabRNA Smart RNA delivery for therapy and diagnostic 150K€ Cerrado

RNAI IN HSC VIA NP Delivery of siRNAs to hematopoietic stem cells using nanopar... 100K€ Cerrado

BacTheRNA Bacterial-Derived Therapeutics based on CircRNAs (BacTheRNA) Cerrado

EXAUTOIMMUNE Extracellular vesicles transcriptomics unravelling the rol... 165K€ Cerrado

Duración del proyecto: 60 meses Fecha Inicio: 2020-01-14
Fecha Fin: 2025-01-31

Líder del proyecto

UNIVERSITAIR MEDISCH CENTRUM UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto RNA-based therapeutics, including siRNA, miRNA, mRNA and CRISPR/Cas9 components, have unprecedented therapeutic potential and hold the promise of treating any disease with a genetic component. However, inefficient delivery into diseased cells hinders their clinical progress. Consequently, there is an urgent need for novel, original approaches to overcome the delivery challenges. Recently, an endogenous RNA transport system has emerged, based on the release and uptake of extracellular vesicles (EVs). EVs are naturally equipped to transfer RNA molecules to other cells in a functional and selective manner. Furthermore, I have recently demonstrated that EVs deliver RNA more efficiently than state-of-the-art synthetic RNA nanocarriers. Thus, EVs hold promise as a new paradigm for RNA delivery. However, the mechanisms underlying EV-mediated RNA transfer are unknown, and reproducible methods for efficient loading of EVs with therapeutic RNA are lacking. The aim of my proposal is to (1) elucidate the mechanisms underlying EV internalization and processing that lead to the functional delivery of their RNA content and (2) radically improve the loading efficiency of EVs for therapeutic RNA delivery. To realize this, I will: 1) Identify genes and pathways involved in EV-mediated RNA transfer using a novel CRISPR/Cas9-based RNA delivery reporter system. 2) Systematically compare uptake and intracellular trafficking of EVs and synthetic nanocarriers. 3) Design a novel and improved method to load EVs with therapeutic RNA. 4) Demonstrate the effect of EV-mediated delivery of therapeutic RNA in a murine model of myocardial infarction. The outcome of this research will fundamentally advance our understanding of the cellular processes enabling EV-mediated RNA transfer, which is of crucial importance for the development of EV-based and EV-inspired delivery systems. This research will accelerate clinical translation of an entire new class of therapeutics based on EVs and RNA.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores