Innovating Works

VESICULOME

Financiado
Origin, evolution and function of bacterial extracellular vesicles in the human...
Origin, evolution and function of bacterial extracellular vesicles in the human host-gut microbiome system Bacterial extracellular vesicles (BEVs) are small membrane vesicles secreted by a diverse range of bacteria that act as bioactive nanocarriers of a high diversity of proteins, lipids and nucleic acids. BEVs have mostly been studie... Bacterial extracellular vesicles (BEVs) are small membrane vesicles secreted by a diverse range of bacteria that act as bioactive nanocarriers of a high diversity of proteins, lipids and nucleic acids. BEVs have mostly been studied in pathogenic bacterial models, owing to their causal role in pathogenicity. Compared to other microbial features, such as taxa, genes or metabolites, BEVs secreted by the large diversity of commensal bacterial species of the human gut microbiota have received little attention so far, leaving their influence upon gut microbial ecology and human health almost entirely unknown. We hypothesize that gut BEVs and their molecular cargos (i.e. the gut bacterial vesiculome) play critical roles in bacteria-bacteria and host-microbiome interactions, and in shaping phenotypes of host-microbiome systems. Our project will enable a comprehensive profiling of BEV molecular diversity across a large number of gut bacterial taxa, and a functional analysis of their impact on inter-species and inter-kingdom interactions. We intend to tackle these objectives through three aims: 1) characterize the origin, diversity and evolution of the human gut bacterial vesiculome; 2) investigate the role of BEVs in promoting horizontal gene transfers among bacterial species in the gut microbiome; and 3) investigate the role of BEVs on bacteria-bacteria and host-bacteria interactions. We will tackle each of these aims from three diversity perspectives: investigating multiple bacterial species, including geographically-distinct healthy human populations, and comparing healthy vs. disease. The project will expand our basic understanding of the evolution and function of bacterial vesiculation. It will also generate the first atlas of BEV profiles across gut bacterial taxa and host cohorts, providing key resources to mine for vesicular characteristics and functions that have translational potential for biomedicine. ver más
31/05/2029
UNIVERSITÄTSKLINIK...
2M€
Perfil tecnológico estimado
Duración del proyecto: 62 meses Fecha Inicio: 2024-03-19
Fecha Fin: 2029-05-31

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-03-19
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2023-COG: ERC CONSOLIDATOR GRANTS
Cerrada hace 1 año
Presupuesto El presupuesto total del proyecto asciende a 2M€
Líder del proyecto
UNIVERSITATSKLINIKUM SCHLESWIGHOLSTEIN No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5