Innovating Works

Circdyn

Financiado
Optical Interrogation of Hippocampal Dentate Granule Circuit Dynamics in Health...
Optical Interrogation of Hippocampal Dentate Granule Circuit Dynamics in Health and Disease Understanding the cellular and synaptic basis of memory remains a central goal of modern neuroscience. Physical traces of memory exist as an enduring, experience-dependent change in neural activity in response to learning. In the... Understanding the cellular and synaptic basis of memory remains a central goal of modern neuroscience. Physical traces of memory exist as an enduring, experience-dependent change in neural activity in response to learning. In the hippocampus, a key region of the mammalian brain involved in memory formation and recall, new neurons are continually generated in the dentate gyrus (DG) where they form an integral part of the existing functional circuitry. Despite its key position in the hippocampal formation, however, the function of DG and its adult-born neurons in vivo has not been carefully investigated. Here, by applying transgenic and optogenetic approaches – including multicolour genetically encoded activity reporters – together with longitudinal two-photon imaging, we aim to study functional dynamics and plastic changes in DG in health and disorder. We propose that activity patterns in DG cell populations show activity-dependent changes during learning and construct a cellular and circuit basis for contextual memory engrams. We will also investigate how synaptic alterations in excitation-inhibition balance and defects in adult neurogenesis in DG lead to neurological disorders such as Rett syndrome. ver más
31/12/2018
UZH
175K€
Duración del proyecto: 27 meses Fecha Inicio: 2016-09-06
Fecha Fin: 2018-12-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2018-12-31
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
MSCA-IF-2015-EF: Marie Skłodowska-Curie Individual Fellowships (IF-EF)
Cerrada hace 9 años
Presupuesto El presupuesto total del proyecto asciende a 175K€
Líder del proyecto
UNIVERSITAT ZURICH No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5