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Occurrence, Regulation, and Function of Bacterial mRNA Editing Under Diverse Env...

Occurrence, Regulation, and Function of Bacterial mRNA Editing Under Diverse Environments "Bacteria are haploid, having a single copy of each gene. We suggest a paradigm shift in bacterial genetics: bacteria can have two RNA versions of the same gene, encoding protein isoforms at the single-bacterium and population lev... see more

31/08/2028

BGU

2M€

Project Budget: 2M€

Project leader

BENGURION UNIVERSITY OF THE NEGEV No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2023-08-14

ERC-2023-STG: ERC STARTING GRANTS Scope:Objectives

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

BGU

1.75M€ | Leader

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Project duration: 60 months Date Start: 2023-08-14
End date: 2028-08-31

Project leader

BENGURION UNIVERSITY OF THE NEGEV No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 2M€

participation deadline Sin fecha límite de participación.

Project description "Bacteria are haploid, having a single copy of each gene. We suggest a paradigm shift in bacterial genetics: bacteria can have two RNA versions of the same gene, encoding protein isoforms at the single-bacterium and population level. These protein isoforms can have altered activity, which could be advantageous under different conditions. Adenosine-to-inosine (A-to-I) mRNA editing can affect the sequence and the function of translated proteins because the ribosome identifies inosine as guanosine. We discovered that A-to-I mRNA editing occurs in bacteria (Escherichia coli), identified the mediating enzyme, and showed that it could affect protein function. Moreover, we discovered that environmental cues experienced during growth in culture affect bacterial mRNA editing. However, the prevalence and regulation of A-to-I mRNA editing across bacteria and the importance of editing for protein function and bacterial physiology in different environments are still unknown. Here, we will test the hypothesis that mRNA editing is widespread in bacteria, producing two RNA ""alleles"" (pseudo-heterozygosity). Subsequently, these RNA ""alleles"" may co-exist in the same bacterial cell or population of cells. Thus, mRNA editing may enable the translation of protein isoforms, making bacteria better adapted to changing environments. We suggest (1) identifying mRNA editing events across environmental conditions in hundreds of species, (2) uncovering the regulatory genetic factors governing bacterial mRNA editing occurrence, and (3) determining the effect of mRNA editing on the proteome and its functional role in bacteria. Our work could shed light on a new mechanism bacteria employ to grow and survive in different environments. Furthermore, bacterial mRNA editing—invisible to DNA sequencing—may account for unsolved problems or phenomena that current genetic and proteomic data cannot explain, affecting bacterial biology and human health."

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