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CATCH

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Novel T cell therapies against lymphocytic leukaemia

Chronic lymphocytic leukaemia (CLL) is the most common type of leukaemia globally and can rarely be cured. Despite recent advances, the efficacy of promising autologous T cell-based therapies, such as CAR-T technology and bi-/tri-... see more

31/12/2023

Academisch Medisch...

150K€

Project Budget: 150K€

Project leader

Academisch Medisch Centrum AMC No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2023-12-31

ERC-2022-POC2: ERC PROOF OF CONCEPT GRANTS2 Objective:Objectives:

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

Academisch Medisch Centrum A...

150.00K€ | Leader

STICHTING AMSTERDAM UMC

150.00K€ | participant

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Project duration: 18 months Date Start: 2022-06-30
End date: 2023-12-31

Project leader

Academisch Medisch Centrum AMC No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 150K€

participation deadline Sin fecha límite de participación.

Project description Chronic lymphocytic leukaemia (CLL) is the most common type of leukaemia globally and can rarely be cured. Despite recent advances, the efficacy of promising autologous T cell-based therapies, such as CAR-T technology and bi-/tri-specific antibodies, has been disappointing. This stems from a T cell dysfunction in this disease setting: altered T cell skewing, impaired metabolic plasticity, and disrupted T-cell functioning. Prof. Arnon Kater's group studies alternative activation pathways to overcome T cell dysfunction and stimulate an immune response. CATCH will explore the technical and commercial feasibility of alternative T-cell activation, through CAR-T and tri-specific antibody technologies. To reach proof-of-concept stage, in this project we will: 1) Validate the efficacy of two applications (CAR-T, tri-specific antibody) by achieving T-cell activation and killing target cells in in-vitro CLL samples and live specimens. 2) Perform a thorough IP landscape analysis, establish Freedom-to-Operate, and define an IP strategy. 3) Engage with key stakeholders to gather feedback and advise from key perspectives (patient, clinical, industry), conduct market research to discover potential customers/industrial partners, analyse competitors and identify a feasible roadmap to commercialisation. 4) Formulate a detailed business case to guide the commercialisation of CATCH.

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