kiNESIS
Financiado
NovEl Strategies for treatIng tendon to bone injurieS kiNESIS
Body movement requires efficient transfer of force from contracting muscles to bone. Damage to the tendinous insertions is the 8th leading cause of disease burden and is the largest single cause of work loss in Europe. Historicall...
Body movement requires efficient transfer of force from contracting muscles to bone. Damage to the tendinous insertions is the 8th leading cause of disease burden and is the largest single cause of work loss in Europe. Historically, approaches for improving healing in these attachment units have focused on modifying repair techniques and rehabilitation protocols. These methods are proven to be very ineffective, since failure rates of as high as 94% are often reported.
We have discovered that two distinct pools of progenitor cells form the tendon-to-bone attachment unit, known as enthesis. Moreover, we showed that these two pools are regulated separately via certain signalling pathways. These recent, yet exciting, findings gave rise to the novel idea that we can use these progenitors to regenerate the unique attachment unit, with the help also of the identified signalling pathways.
The overall goal of our ERC PoC project is to take the first steps towards the development and pre-commercialisation of novel regenerative strategies for enhanced tendon-to-bone healing in the adult setting. Specifically, (1) the first target is to establish the technical feasibility of our idea by performing a series of in-vitro and in-vivo-experiments, the latter utilising a novel state-of-the-art rotator cuff enthesis injury model that we developed. If the results of our preclinical studies are successful, they will have a direct impact on future regenerative strategies for tendon-to-bone repair. (2) The second target of the kiNESIS project is to establish the commercialisation potential of our idea. The commercialisation can result in a truly revolutionising, simple and non-invasive needle-based therapy for tendon injuries.
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Duración del proyecto: 18 meses
Fecha Inicio: 2017-03-13
Fecha Fin: 2018-09-30
Fecha Fin: 2018-09-30
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2018-09-30
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-PoC-2016:
ERC-Proof of Concept-2016
Cerrada
hace 8 años
Presupuesto
El presupuesto total del proyecto asciende a
150K€
Líder del proyecto
WEIZMANN INSTITUTE OF SCIENCE
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
1.30M€ |
Participante