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COSMOPHOS-NANO

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Novel nanotechnology enabled system for endovascular in vivo near infrared fluor...

Novel nanotechnology enabled system for endovascular in vivo near infrared fluorescence molecular imaging and endovascular near infrared targeted photodynamic therapy of atherosclerotic heart disease CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives: 1) develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechno... ver más

28/02/2018

UNIVERSITY OF EAST...

13M€

Presupuesto del proyecto: 13M€

Líder del proyecto

ITASUOMEN YLIOPISTO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 17 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2018-02-28 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

17 Participantes

UNIVERSITY OF EASTERN FINLAN...

0.00€ | Lider

KUOPIO UNIVERSITY HOSPITAL

N.D. | Participante

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Líder del proyecto

ITASUOMEN YLIOPISTO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 13M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives: 1) develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechnology-enabled portable combination system enabling endovascular in vivo near-infrared fluorescence molecular imaging, endovascular near-infrared targeted photodynamic therapy, real-time & follow-up therapy monitoring of atherosclerotic coronary artery disease (CAD), 2) nonclinically evaluate this system, 3) clinically validate the system after regulatory approval, & 4) reduce in the long-term CAD deaths and morbidity by up to 40%, resulting in a significant decrease of the European and global healthcare costs for CAD, increasing the income of the European healthcare industry from CAD market which is the global largest. The CosmoPHOS-nano consortium has a five year history of successful collaboration between the industrial and academic partners, and its funding would underpin a team devoted to delivering a novel powerful & affordable healthcare solution against the leading cause of death, without the need for heavy and expensive medical equipment. The CosmoPHOS system consists of two interacting components: a) targeted theranostic near-infrared photoactivatable biocompatible nanomedicines, and b) medical devices. After systemic administration, the nanomedicines targeted accumulate in coronary atherosclerotic plaques, followed by endocoronary photoactivation and detection by the medical devices, enabling molecular imaging, targeted therapy, real-time & follow-up therapy monitoring of CAD. Preliminary in vitro & in vivo successful experimental results, as well as parts of the CosmoPHOS system are already available from the prior five year collaboration. The project plan includes: A) nonclinical R&D (30 months); B) nonclinical validation & regulatory approval (18 months); C) first-in-man phase-I clinical trial in 20 CAD patients (12 months).

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