Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MATRIXASSAY

Financiado

Novel Cell Migration Assay Based on Microtissue Technology and Tissue Specific M...

Novel Cell Migration Assay Based on Microtissue Technology and Tissue Specific Matrices Cell migration assays are commonly used to study wound healing, cancer cell invasion, and tissue development. Problems associated with the gap closure assays typically employed are that: (i) the stopper or scratch used to make th... ver más

31/05/2019

NUID UCD

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 12 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-05-31

MSCA-RISE-2014: Marie Skłodowska-Curie Research and...

I+D

Cerrada hace 10 años

0% 88% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

12 Participantes

NUID UCD

216.00K€ | Lider

EMBEGA

187.89K€ | Participante

GRIFFITH UNIVERSITY

MSC

27.00K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BUCKLING BRIDGES Smart wavy patterned implants with instructive properties fo... 150K€ Cerrado

PDC2021-121515-I00 PLACAS DE CULTIVO CELULAR NANOESTRUCTURADAS 136K€ Cerrado

TEC2013-48552-C2-2-R PROPIEDADES VISCOELASTICAS E INTERACCION MECANICA DE CELULAS... 108K€ Cerrado

PID2020-113819RB-I00 DISEÑO DE IMPLANTES PARA TERAPIA TUMORAL Y REGENERACION OSEA... 151K€ Cerrado

METABOLATE METABOLic immuno-engineered biomATErials 242K€ Cerrado

EQC2019-005478-P Adquisición de un sistema de videomicroscopía para cultivo c... 237K€ Cerrado

Duración del proyecto: 49 meses Fecha Inicio: 2015-04-23
Fecha Fin: 2019-05-31

Líder del proyecto

UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto Cell migration assays are commonly used to study wound healing, cancer cell invasion, and tissue development. Problems associated with the gap closure assays typically employed are that: (i) the stopper or scratch used to make the migration zone damages the extracellular matrix (ECM), (ii) the migration zone size is limited by the size of the stopper, and (iii) the scratched migration zone shapes and sizes are irreproducible. Cell migration is strongly coupled with the structure and mechanical properties of the ECM, and damage to the ECM alters the cell migration path. The main objective of this project is to develop a prototype novel cell migration assay, which will significantly improve the predictive power of cell-based assays while avoiding problems associated with existing assays, based on seeding cells precisely on pristine extracellular matrix tissue mimics with native-like cell-functionality and reproducible migration zones. In accomplishing this, we will also address the following questions: • What are the structure-property relationships between collagen I matrices with controlled thicknesses and fibril diameter and alignment, and their mechanical and electromechanical properties? • What are the critical parameters for achieving functional bonding between the substrate and the highly anisotropic viscoelastic collagen I matrices and controlling the overall mechanical properties? • Does the distribution of collagen fibril polar ordering, i.e., piezoelectric domains, influence cell migration? • What parameters control crimp formation in tendon-like collagen I matrices? • What parameters control and explain the unusual viscoelastic properties (e.g., they not depend on the speed of deformation, at least within the interval 0.01 - 1 mm/sec) of tendon-like collagen matrices? • Which cell types, including cancer cells, co-align with collagen fibril alignment or crimp direction?

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores