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Nonlinearity assisted Optical Focusing and Imaging Deep Inside Scattering Media

Focusing light to the (sub)micron scale is the enabling element in many important biomedical and industrial applications, such as optical microscopy and laser nano-surgery. However, the inherent inhomogeneity of biological tissues... ver más

31/05/2015

CNRS

270K€

Presupuesto del proyecto: 270K€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-05-31 No tenemos la información de la convocatoria

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1 Participantes

CNRS

0.00€ | Lider

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Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 270K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Focusing light to the (sub)micron scale is the enabling element in many important biomedical and industrial applications, such as optical microscopy and laser nano-surgery. However, the inherent inhomogeneity of biological tissues induces light scattering which limits effective focusing to shallow depths of a few hundred microns. As a result, optical microscopy, perhaps the most important tool in biological discovery and medical investigation, is currently restricted to superficial investigation. Nevertheless, recent results have shown that the effects of such random scattering can be undone, controlled, and even exploited by high-resolution wavefront shaping. The goal of this project is to use these novel insights to break the resolution limit of deep-tissue optical techniques, and enable controlled sub-micron focusing and microscopic imaging deep in scattering media. This ambitious goal will be achieved by combining the powerful techniques of the emerging field of wavefront shaping where leading contributions have been made by the applicant and the host, with the penetration depth allowed by photoacoustics, field in which the host has a world-leading expertise. We will be able to go beyond the acoustic wavelength resolution limit of photoacoustics by exploiting nonlinear photoacoustic effects as the control signal for adaptive light focusing, an original insight discovered by the joint work of the applicant and the host in the last few months. Achieving the project’s goal would be both a scientific and technological breakthrough as well as a having a huge potential impact on societal issues, with the hope of substituting invasive biopsy procedures and allowing imaging through complex samples in industry.

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