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Non linear temporal dynamics of mutually inhibiting pyramidal cells underlying...

Non linear temporal dynamics of mutually inhibiting pyramidal cells underlying mechanism for bi stable perception and disambiguation Bi-stable perception has been the key tool to investigate how retinal information reaches consciousness. In existing theoretical work to explain this phenomenon, it has been assumed that a neural circuit, called mutual inhibition,... ver más

30/06/2020

STICHTING RADBOUD...

166K€

Presupuesto del proyecto: 166K€

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STICHTING RADBOUD UNIVERSITEIT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-06-30

MSCA-IF-2017: Individual Fellowships Objective:The goal of the Individual Fellowships is to enhance the creative and innovative potential...

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STICHTING RADBOUD UNIVERSITE...

165.60K€ | Lider

BODEGAS TERRAS GAUDA

811.11K€ | Participante

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Duración del proyecto: 27 meses Fecha Inicio: 2018-03-19
Fecha Fin: 2020-06-30

Líder del proyecto

STICHTING RADBOUD UNIVERSITEIT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 166K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Bi-stable perception has been the key tool to investigate how retinal information reaches consciousness. In existing theoretical work to explain this phenomenon, it has been assumed that a neural circuit, called mutual inhibition, plays the key role in perceptual alternations. Two neurons (or neuron groups) representing competing percepts inhibit each other and one becomes dominant while another becomes suppressed. Adaptation of the dominant neuron and recovery of suppressed neuron causes the reversal of the dominance after few seconds. While there are elaborate theoretical models implementing this circuit, its physiological data from real neurons is missing. I will use in vitro preparation combined with a state-of-art dynamic clamp system where the disynaptic inhibitory connections between two real pyramidal cells are established by model synapses and inhibitory neuron models. I will run paradigms equivalent to experimental paradigms known in the research of bi-stable perception. In this way, I aim at elucidating the neurophysiological factors underlying the known dynamical properties of bi-stable perception. I will investigate how dominance durations and their distributions are influenced by the activity levels of the two neurons (equivalent to the well-known Levelt’s propositions), how their stochasticity is influenced by noise, how memory effect can be observed, and how feedback projection influences their dynamics. There is often an ambiguity in input images due to noise or conflicting information. Coherent representation of such input can be established if the mutually inhibiting neurons representing conflicting cues are influenced by feedback such that the neural signals consistent with global properties are enhanced. Therefore, mutual inhibition may work as a fundamental unit of signal processing in establishing coherent perception. This project will elucidate this essential mechanism underlying perceptual organization.

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