NAKED-C
Financiado
New late-stage functionalization reagents for the construction of chiral centers...
New late-stage functionalization reagents for the construction of chiral centers to impact drug discoveryhis her
Late-stage functionalization (LSF) is a rapidly expanding field in molecular synthesis with the major goal of quickly accessing to derivatives that would be too challenging or time-consuming to prepare otherwise; hence, this strat...
Late-stage functionalization (LSF) is a rapidly expanding field in molecular synthesis with the major goal of quickly accessing to derivatives that would be too challenging or time-consuming to prepare otherwise; hence, this strategy has a great potential to impact drug discovery processes by speeding up the hit-to-lead optimization. At present, more than two-thirds of prescription drugs contain at least one chiral center. However, the late-stage introduction of this structural motif using aromatic C–H bonds is an enduring challenge in synthesis. The goal of the NAKED-C project is to develop a new methodology for the construction of chiral centers in drug molecules, relying on the design and synthesis of a novel class of atomic carbon precursors that, upon successive and appropriate activations, would allow to build tailored asymmetric carbons. To achieve this goal, a new visible-light photoredox catalytic diazomethylation of aromatic C–H bonds will be developed. The collaboration with an industrial partner (secondment at AiCuris) will allow the application of this novel strategy to drug discovery in the search of effective antibiotics, thus merging multidisciplinary aspects with intersectoral knowledge transfer. The result will be a brand-new ‘assembly point’ for the construction of chiral centers in bioactive compounds, with the potential to become a late-stage diversity-generating synthetic platform for drug discovery programs. The proposal merges the host expertise in novel C−H functionalization strategies based on photocatalysis, and the researcher’s background in classical radical chemistry, metal-mediated synthesis and pharmacology, ensuring the two-way transfer of knowledge between the fellow and the host group. Successful development of NAKED-C will enhance the scientific and transferable skills of the researcher, while forthcoming to the fellow’s professional goal of pursuing an independent research career in academia in synthetic organic chemistry.
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Duración del proyecto: 36 meses
Fecha Inicio: 2023-07-07
Fecha Fin: 2026-07-31
Fecha Fin: 2026-07-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-07-07
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2022-PF-01-01:
MSCA Postdoctoral Fellowships 2022
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
181K€
Líder del proyecto
FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMI...
Otra investigación y desarrollo experimental en ciencias naturales y técnicas asociacion
Perfil tecnológico
TRL
4-5
50K
Perfil tecnológico
TRL
4-5
50K
N.D. |
Participante