Innovating Works

REANIMA

Financiado
New generation cardiac therapeutic strategies directed to the activation of endo...
New generation cardiac therapeutic strategies directed to the activation of endogenous regenerative mechanisms Heart failure is a major epidemic world-wide, resulting in a large burden for society in deaths, morbidity and economic sustainability. The inability of the human heart to regenerate the myocardium lost due to acute myocardial inf... Heart failure is a major epidemic world-wide, resulting in a large burden for society in deaths, morbidity and economic sustainability. The inability of the human heart to regenerate the myocardium lost due to acute myocardial infarction underlies a large part of chronic heart failure cases. To tackle this problem, REANIMA aims to deliver new therapies for heart regeneration, thereby reverting the conditions that lead to heart failure. Thus far, clinical trials based on introducing stem cells into the heart have not shown regenerative ability. In contrast, studies of spontaneous and induced heart regeneration in animal models strongly suggest a change in paradigm towards the reactivation of endogenous regenerative mechanisms. To develop this new path, REANIMA presents the first European basic-translational integrated effort in the cardiac regenerative field, with activities that span from the discovery of new targets in animal models to clinical trial design. REANIMA brings together knowledge on species that can regenerate their hearts –fish and amphibians–, animals that cannot regenerate their hearts –adult mammals– and human engineered heart tissues. Strong synergy between partners will allow REANIMA to identify new pathways in regenerative animals and design strategies for their reactivation in non-regenerative animals and human tissue. REANIMA incorporates industrial and academic partners specialised in translational and pre-clinical research, who will develop advanced therapeutic medicinal products and new translational platforms. REANIMA will thus establish a translational pipeline using cross-species gene/protein therapy products with high translational potential, thereby boosting the rapid transition from basic research to the design of clinical trials. We expect that REANIMA will change current paradigms underlying clinical efforts in regenerative cardiology by transforming basic knowledge on endogenous pathways into effective new therapies. ver más
30/06/2025
CENTRO NACIONAL DE...
8M€
Duración del proyecto: 66 meses Fecha Inicio: 2019-12-12
Fecha Fin: 2025-06-30

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2019-12-12
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
SC1-BHC-07-2019: Regenerative medicine: from new insights to new applications
Cerrada hace 5 años
Presupuesto El presupuesto total del proyecto asciende a 8M€
Líder del proyecto
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASC... No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5 28M