Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

COxEnzymes - AGs

Financiado

New Carbohydrate Oxidising Enzymes prepared by directed evolution and their appl...

New Carbohydrate Oxidising Enzymes prepared by directed evolution and their application in synthesis of AminoGlycoside derivatives with antibiotic potential and rare sugars. Carbohydrate-oxidising enzymes (COE) are a group of enzymes which are active on specific carbohydrates and can use molecular oxygen as a mild oxidant. Oxidation is typically directed towards specific positions of the sugar ring. R... ver más

31/05/2026

UNL

173K€

Presupuesto del proyecto: 173K€

Líder del proyecto

UNIVERSIDADE NOVA DE LISBOA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-03-05

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

I+D

Cerrada hace 1 año

0% 100%

1 Participantes

UNL

172.62K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

CTQ2010-19073 ESTUDIOS SOBRE RECONOCIMIENTO MOLECULAR DE AMINOGLICOSIDOS P... 103K€ Cerrado

BIO2010-15226 MECANISMOS DE SINTESIS Y SECRECION DE LA PROTEINA ANTIMICROB... 109K€ Cerrado

PTQ-11-04955 Desarrollo de procesos de síntesis enzimática de compuestos... 78K€ Cerrado

CTQ2014-60250-R DESARROLLO DE PROCESOS ENZIMATICOS PARA SU EMPLEO EN LA BIOP... 157K€ Cerrado

breakingBAC Breaking resistance of pathogenic bacteria by chemical dysre... 2M€ Cerrado

BIO2009-10334 BIOLOGIA ESTRUCTURAL DE HIDROLASAS DE INTERES TERAPEUTICO (I... 368K€ Cerrado

Duración del proyecto: 26 meses Fecha Inicio: 2024-03-05
Fecha Fin: 2026-05-31

Líder del proyecto

UNIVERSIDADE NOVA DE LISBOA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 173K€

Descripción del proyecto Carbohydrate-oxidising enzymes (COE) are a group of enzymes which are active on specific carbohydrates and can use molecular oxygen as a mild oxidant. Oxidation is typically directed towards specific positions of the sugar ring. Regioselectivity and substrate specificity relies on the architecture of active site, therefore the direct evolution approach in this project will allow to generate a toolbox of effective and regiospecific catalysts to modify various carbohydrate scaffolds. Our aim is to use this toolbox to generate a library of bioactive compounds: i) aminoglycoside derivatives starting with analogues of Kanamycin as candidates to help in the fight against the global problem of antimicrobial resistance. This process in combination with a further chemical step may lead to a large library of derivatives prepared in short time with only a two-step chemoenzymatic process; ii) rare monosaccharides and oligosaccharides as promising candidates with health benefits. Antimicrobial activities of prepared library of compounds will be measured and statistically evaluated. Furthermore, this project will advance the current knowledge of COE which is of utmost interest for fundamental biology and crucial for industrial biotechnology and chemistry applications. Biocatalysis will be applicable to the synthesis of a wide range of saccharide related compounds, solving one of the big challenges in carbohydrate chemistry, the regioselective differentiation of the OH groups, in a green, sustainable and very efficient way.

Conecta tu I+D

Entra hoy

¿Olvide mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores