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MyelinPlasticity

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Neuronal regulation of CNS myelin plasticity

Myelin is essential for normal brain function, as it provides fast signal transmission, promotes synchronisation of neuronal signals and helps to maintain neuronal function. Alterations in myelination are increasingly being implic... ver más

30/11/2023

THE CHANCELLOR MAS...

2M€

Presupuesto del proyecto: 2M€

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THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-11-30

ERC-2017-COG: ERC Consolidator Grant Scope:Objectives

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2 Participantes

THE CHANCELLOR MASTERS AND S...

2.00M€ | Lider

FAGOR ELECTRONICA

485.26K€ | Participante

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Duración del proyecto: 67 meses Fecha Inicio: 2018-04-10
Fecha Fin: 2023-11-30

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Myelin is essential for normal brain function, as it provides fast signal transmission, promotes synchronisation of neuronal signals and helps to maintain neuronal function. Alterations in myelination are increasingly being implicated as a mechanism for sensory-motor learning. The importance of myelin becomes evident in diseases, such as multiple sclerosis (MS), where myelin damage causes cognitive and motor disability. Moreover, recent studies have highlighted the contribution of myelin to many diseases that were previously considered to be ‘neuronal’, such as dementia, schizophrenia, autism and bipolar disorder. Despite the profound importance of myelin, there are serious deficits in our understanding of how myelination is regulated and to what extent myelin is plastic; which are impediments for understanding both the functional connectivity of the central nervous system (CNS) and white matter disease. We, and others, have shown that myelination can be regulated by neuronal activity, thus I hypothesize that neuronal activity is a driver of myelin plasticity, similar to synaptic plasticity. By using an innovative approach combining electrophysiology, optogenetics, pharmacogenetics, imaging, transgenic animals, behavioural tests, and in vitro and in vivo models of myelination, this research programme will determine mechanisms that mediate neuronal activity dependent myelination, establish to what extent myelin changes occur with learning and identify to what extent myelin is plastic. The outcome of this proposal will break new ground in our understanding of myelin plasticity, and has the potential to provide novel therapeutic strategies for myelin regeneration in white matter diseases such as MS.

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