Neuron to Egg Laying
Financiado
Neuronal Control of Fine Movement Components of Egg Laying in Fruit Fly
[a short summary to be written shortly]Insect reproduction has a large impact in human well-being through the dissemination of disease and crop failure. Here, we propose to study insect egg laying using Drosophila melanogaster as...
[a short summary to be written shortly]Insect reproduction has a large impact in human well-being through the dissemination of disease and crop failure. Here, we propose to study insect egg laying using Drosophila melanogaster as a model system. We will focus on the ventral nerve cord and its role in executing egg laying behaviour commands. We will take advantage of lines previously generated in the laboratory that label small groups of neurons in the ventral nerve cord to establish how different neurons contribute to egg laying motor elements and explore how they communicate with each other and other identified egg laying neuronal elements to coordinate the execution of the different egg laying steps. For this we will pursue the following aims: Aim1- Development of automated tracking of each element of egg laying behaviour. This will allow a precise, quantitative and fast description of behavioural phenotypes; Aim2- Probe the contribution of different motor-controlling neuronal populations to different elements of egg laying behaviour.Activation phenotypes will be recorded, classified and clustered for each ventral nerve cord line; Aim3 - Establish the connectivity of different neuronal populations.The power of Drosophila genetics will be used determine through anatomical and functional means the connectivity between different sets of neurons, including descending neurons from the brain and other local ventral nerve cord neurons. We will also determine how octopamine modulates the functional connectivity between the neurons.
With the results of this project, we expect to produce important insights into the mechanisms of control and execution of egg laying behaviour.
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Duración del proyecto: 33 meses
Fecha Inicio: 2023-11-23
Fecha Fin: 2026-08-31
Fecha Fin: 2026-08-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-11-23
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
Presupuesto
El presupuesto total del proyecto asciende a
173K€
Líder del proyecto
FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR....
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5