Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

NSFCSTRANSPLANTATION

Financiado

Cerrado

Neuronal and glial fate of neurosphere forming cells from olfactory neuroepithel...

Neuronal and glial fate of neurosphere forming cells from olfactory neuroepithelium Recently, the design of new brain repair strategies based on stem cell transplantation has received a tremendous amount of attention. This has been due to the increased incidence of neurodegenerative diseases and the absence of ef... ver más

31/03/2012

FONDAZIONE SANTA L...

45K€

Presupuesto del proyecto: 45K€

Líder del proyecto

FONDAZIONE SANTA LUCIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2012-03-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

FONDAZIONE SANTA LUCIA

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

NEUROSTEMCELLREPAIR European stem cell consortium for neural cell replacement r... 8M€ Cerrado

SAF2008-01006 INTEGRACION DE SEÑALES EN LA REGULACION DE LA AUTO-RENOVACIO... 351K€ Cerrado

NEUROSTEMCELL European Consortium for Stem Cell Therapy for Neurodegenerat... 16M€ Cerrado

TREAT-PD Patient specific treatment for Parkinson s disease using rep... 2M€ Cerrado

BEND Bendable Bioplatform for Electrically stimulated Neuronal Di... 195K€ Cerrado

STEM ZAP Optogenetics based discovery of new pathways towards stem ce... 195K€ Cerrado

Líder del proyecto

FONDAZIONE SANTA LUCIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 45K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Recently, the design of new brain repair strategies based on stem cell transplantation has received a tremendous amount of attention. This has been due to the increased incidence of neurodegenerative diseases and the absence of effective chemically based therapies. In this context the potential use of stem cells for transplantation appears as a promising alternative to restore lost cells (i.e. neurons or oligodendrocytes) in the central nervous system (CNS). In this context, adult neural progenitors derived from olfactory neuroepithelium could constitute an excellent candidate. Olfactory neuroepithelium is a unique source of adult human progenitors, which can be obtained from an individual without invasive surgery. These cells have the capacity to continually replace damaged neurons and glia throughout life; they can be amplified in vitro and create neurospheres and they can adopt a neuronal or glial fate depending on environmental factors. They survive, integrate and are functional when transplanted into a rat model of injured spinal cord. We propose to further study olfactory neuroepithelium cells and to develop in vitro amplification and differentiation procedures to obtain a pure population of committed progenitors for transplantation into damaged CNS or for use in drug research, pharmacological evaluation and gene manipulation. As a first step to use adult olfactory progenitors to facilitate CNS repair, we propose to test the capacity of these cells to differentiate into dopaminergic phenotype and investigate their restorative capacity when grafted into a denervated striatum. Analogously, the potential of adult olfactory progenitors to differentiate into oligodendrocytic phenotype and to restore oligodendrocytes will be evaluated in hypomyelinated corpus callosum of mice affected by genetically determined myelinopathy (shiverer mice).

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores