An expectant mother’s brain undergoes dramatic structural remodeling during pregnancy. These changes are thought to be elicited by hormones, orchestrating the behavioural and physiological adaptations necessary for infant care. De...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
PID2019-107322GB-C21
SUSTRATO SENSORIAL, NEURAL Y ENDOCRINO DE LA MOTIVACION MATE...
108K€
Cerrado
PID2019-106032GB-I00
PROGRAMACION DEL COMPORTAMIENTO SOCIAL A TRAVES DE EFECTOS M...
122K€
Cerrado
DRIVOME
Multi modal interrogation of instinctive behaviours and intr...
183K€
Cerrado
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
An expectant mother’s brain undergoes dramatic structural remodeling during pregnancy. These changes are thought to be elicited by hormones, orchestrating the behavioural and physiological adaptations necessary for infant care. Despite the scale of these effects, we know little about the neural mechanisms by which pregnancy affects the brain. Recent methodological advances now offer the exciting opportunity to address these questions. This project will use a multidisciplinary approach to uncover the molecular, cellular and circuit-level mechanisms of pregnancy hormone action in a mouse model.
We will first focus on which aspects of parenting, feeding and aggression are affected by pregnancy – and over which time course these behavioural adaptations occur. This will provide important clues about the nature of underlying neural plasticity mechanisms. Next, we will determine which nodes of the circuits controlling these behaviours are sensitive to pregnancy hormones. This will then allow us to address the functional consequences of pregnancy at the network level, using in vivo calcium imaging approaches. Finally, we will study the biophysical and cellular mechanisms underlying pregnancy hormone action in genetically defined neurons, through a combination of electrophysiology and transcriptomic profiling.
By integrating these complementary lines of evidence, we aim to obtain a mechanistic understanding of the neural adaptations occurring during pregnancy. I believe that these innovative studies will generate novel and highly generalizable insights into how physiological states shape information processing in the brain.