Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

PregnantBrain

Financiado

Neural adaptations during pregnancy

An expectant mother’s brain undergoes dramatic structural remodeling during pregnancy. These changes are thought to be elicited by hormones, orchestrating the behavioural and physiological adaptations necessary for infant care. De... ver más

31/05/2025

The Francis Crick...

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

THE FRANCIS CRICK INSTITUTE LIMITED No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-11-18

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2019-STG: ERC Starting Grant

I+D

Cerrada hace 6 años

0% 100%

2 Participantes

The Francis Crick Institute

1.49M€ | Lider

IMPORTACO CASA PONS

711.61K€ | Participante

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 66 meses Fecha Inicio: 2019-11-18
Fecha Fin: 2025-05-31

Líder del proyecto

THE FRANCIS CRICK INSTITUTE LIMITED

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto An expectant mother’s brain undergoes dramatic structural remodeling during pregnancy. These changes are thought to be elicited by hormones, orchestrating the behavioural and physiological adaptations necessary for infant care. Despite the scale of these effects, we know little about the neural mechanisms by which pregnancy affects the brain. Recent methodological advances now offer the exciting opportunity to address these questions. This project will use a multidisciplinary approach to uncover the molecular, cellular and circuit-level mechanisms of pregnancy hormone action in a mouse model. We will first focus on which aspects of parenting, feeding and aggression are affected by pregnancy – and over which time course these behavioural adaptations occur. This will provide important clues about the nature of underlying neural plasticity mechanisms. Next, we will determine which nodes of the circuits controlling these behaviours are sensitive to pregnancy hormones. This will then allow us to address the functional consequences of pregnancy at the network level, using in vivo calcium imaging approaches. Finally, we will study the biophysical and cellular mechanisms underlying pregnancy hormone action in genetically defined neurons, through a combination of electrophysiology and transcriptomic profiling. By integrating these complementary lines of evidence, we aim to obtain a mechanistic understanding of the neural adaptations occurring during pregnancy. I believe that these innovative studies will generate novel and highly generalizable insights into how physiological states shape information processing in the brain.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores