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Immuno-NanoDecoder

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Nanostructured molecular decoders for the quantitative multiplexed layer by la...

Nanostructured molecular decoders for the quantitative multiplexed layer by layer detection of disease associated proteins The long-range goal of this project is to develop a molecular nanodevice, based on nucleic acid-protein conjugates, for the multiplexed, quantitative imaging of biomarkers in tissue samples and cultured cells. The Immuno-nanodecod... ver más

31/03/2019

UNITOV

441K€

Presupuesto del proyecto: 441K€

Líder del proyecto

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 7 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-03-31

MSCA-RISE-2014: Marie Skłodowska-Curie Research and...

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7 Participantes

UNITOV

198.00K€ | Lider

UNIVERSITY OF LINCOLN

63.00K€ | Participante

CONSEJO NACIONAL DE INVESTIG...

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Duración del proyecto: 52 meses Fecha Inicio: 2014-11-10
Fecha Fin: 2019-03-31

Líder del proyecto

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 441K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The long-range goal of this project is to develop a molecular nanodevice, based on nucleic acid-protein conjugates, for the multiplexed, quantitative imaging of biomarkers in tissue samples and cultured cells. The Immuno-nanodecoder will be used for the accurate molecular characterization of skin cancer (melanoma) and glycogenosis type II cellular models and to evaluate the in vitro response to experimental therapies. The nanodevices (nanodecoders) will consist of self-assembled DNA nanostructures that can reversibly change their fluorescence signal output in response to hybridization to nucleic acid sequences, or to a specific enzymatic reaction. Each nanodevice will be coupled to a specific molecular probe, such as an antibody, peptide, or protein that uniquely recognize disease biomarkers. The coupling will allow the nanodecoder to detect biomarker presence and distribution in cells and tissues, in a layer-by-layer fashion, using optical fluorescence microscopy. The number of biomarkers that can be detected will be limited only by the capacity to design nanodecoders with differing specificities, which is essentially unlimited. The creation of nanodecoders and optimization of their function will greatly advance biomarker imaging, which currently lacks a high-throughput, convenient method for the in situ, quantitative microscopic analysis of altered tissue regions. This project will be driven by knowledge exchange and the expertise of an interdisciplinary team comprised of both early-stage and experienced university and hospital researchers. Complementary research programs, ranging from nanotechnology to molecular medicine and pathology will support each step of the developmental and applicative parts of the project towards the achievement of its objectives. Funding of this program will enable long-term, transformative collaborations that will contribute to the integration and collaboration of research groups between European Countries and key Third Countries.

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