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NanoCHROMS

Financiado

Nanoscale Chromatin Response to Mechanical Stimulus

Cells respond to physical stimuli from their environment, drastically changing their chromatin organization. Direct nuclear mechanotransduction affects cell behavior, but this mechanism is still not fully understood. This unsolved... ver más

31/08/2027

FUNDACION IMDEA NA...

165K€

Presupuesto del proyecto: 165K€

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FUNDACION IMDEA NANOCIENCIA Otra investigación y desarrollo experimental en ciencias naturales y técnicas asociacion

TRL 4-5 | 130K€

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-05-13

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

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FUNDACION IMDEA NANOCIENCIA

165.31K€ | Lider

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Duración del proyecto: 39 meses Fecha Inicio: 2024-05-13
Fecha Fin: 2027-08-31

Líder del proyecto

FUNDACION IMDEA NANOCIENCIA Otra investigación y desarrollo experimental en ciencias naturales y técnicas asociacion

TRL 4-5 | 130K€

Presupuesto del proyecto 165K€

Descripción del proyecto Cells respond to physical stimuli from their environment, drastically changing their chromatin organization. Direct nuclear mechanotransduction affects cell behavior, but this mechanism is still not fully understood. This unsolved link is due to the difficulty of finding tools to generate precise mechanical signals and observe changes in chromatin at the nanoscale level. NanoCHROMS aims to understand the effect of nuclear mechanotransduction on nuclear architecture. We aim to characterize the mechanism driving localized chromatin structure changes in response to direct physical stimuli, and how these changes relate to cellular state. NanoCHROMS will exploit two novel and powerful technologies, Nanofabrication and Single Molecule Localization Microscopy (SMLM). For that, we will use nanopillars as nanomechanical actuators. By culturing somatic, stem and cancer cells in a fabricated nanopillar surface, purposely designed to be SMLM-compatible, we can exert a precise, controlled, and replicable force in the nucleus. Using SMLM, we can unveil higher order chromatin folding with nanometric precision, obtaining positional information of DNA and nucleosome packaging, directly related to cell function. By using SMLM in cells growing on nanopillared surfaces, we can establish the changes of chromatin in direct relation to the physical point of application of the stimulus at the nanoscale. Finally, using sequence-specific imaging approaches (Oligopaints) we will study the nuclear positioning and compaction of genes whose expression is drastically affected by mechanotransduction. NanoCHROMS will contribute to understanding the mechanisms driving expression changes, maintenance of stemness and oncogenesis by mechanostimulus, being a steppingstone in projects working in the interface between cell biology and nanomaterials science. Finally, NanoCHROMS will develop a systematic and quantitative method to evaluate the effect of different nanostructures on nuclear architecture.

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