Nanoagent based three method treatment for atherosclerosis Combination of therm...
Nanoagent based three method treatment for atherosclerosis Combination of thermal mechanical and drug based methods
The aim of NanoTAS is to propose a novel three-method treatment for the atherosclerosis (AS) disease based on nano-structured agents (NAs), which incorporates three kinds of methods into a single one: 1) Thermal treatment, 2) Mech...
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31/01/2025
UGR
165K€
Presupuesto del proyecto: 165K€
Líder del proyecto
UNIVERSIDAD DE GRANADA
No se ha especificado una descripción o un objeto social para esta compañía.
Total investigadores5533
Fecha límite participación
Sin fecha límite de participación.
Financiación
concedida
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el día 2025-01-31
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Información proyecto NanoTAS
Duración del proyecto: 31 meses
Fecha Inicio: 2022-06-28
Fecha Fin: 2025-01-31
Líder del proyecto
UNIVERSIDAD DE GRANADA
No se ha especificado una descripción o un objeto social para esta compañía.
Total investigadores5533
Presupuesto del proyecto
165K€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
The aim of NanoTAS is to propose a novel three-method treatment for the atherosclerosis (AS) disease based on nano-structured agents (NAs), which incorporates three kinds of methods into a single one: 1) Thermal treatment, 2) Mechanical treatment, and 3) Anti-AS drug-based treatment. The NAs employed in the NanoTAS are proposed to have a novel composite structure including magnetic agents (ferrite-based nanorods; FNRs) and plasmonic agents (Au nanostars; AuNSs). Thermal treatment is accomplished through magneto-photo thermal therapy (MPTT), a combination of magnetic hyperthermia therapy (MHT) using FNRs under alternating magnetic field (AMF) and photothermal therapy (PTT) using AuNSs under near-infrared laser (NIR-laser) while mechanical treatment is performed through rotation of NAs (by their magnetic part i.e. FNRs) under rotating magnetic field (RMF). The NAs also load anti-AS drug and deliver it to target sites through a biocompatible and thermo-sensitive polymer. Accordingly, the specific objectives of NanoTAS can be summarized as: Oi) Decreasing the inflammation in blood vessels involved in the AS through thermal treatment (MPTT). Oii) Targeted release of anti-AS drug using a thermo-sensitive mechanism triggered by thermal treatment. Oiii) Breaking and abrading plaques using mechanical treatment through rotation of NAs under RMF. The objectives are achieved through applying the external stimuli on the drug-loaded NAs, during the following steps: Step 1) Applying both AMF and NIR-laser: This is a two-purpose step in which thermal treatment is accomplished aiming both decrease in inflammation (Oi) and drug release (Oii). Step 2) Applying RMF: This step is applied for breaking and chipping the structure of plaques (Oiii). Step 3) Repeating the step 1: This step is a supplementary one to decrease in remaining inflammation (Oi).