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NanoIntra

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Multitasking Nanoparticles for Intracellular Bioimaging and Biosensing

The development of specifically designed nanomaterials for advanced medical applications such as theranostics has become a major technical challenge with great potential societal and economic outcomes. Nanomedicine and related tec... ver más

30/04/2020

UGent

259K€

Presupuesto del proyecto: 259K€

Líder del proyecto

UNIVERSITEIT GENT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-04-30

MSCA-IF-2015-GF: Marie Skłodowska-Curie Individual F... Scope:Proposals for Global Fellowships involve a single host organisation (future beneficiary) estab...

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

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3 Participantes

UGent

258.53K€ | Lider

CORNELL UNIVERSITY

172.13K€ | Participante

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Duración del proyecto: 50 meses Fecha Inicio: 2016-02-18
Fecha Fin: 2020-04-30

Líder del proyecto

UNIVERSITEIT GENT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 259K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The development of specifically designed nanomaterials for advanced medical applications such as theranostics has become a major technical challenge with great potential societal and economic outcomes. Nanomedicine and related techniques hold great promises for improved diagnostic and treatment of widely spread diseases such as cancer. This project, entitled NanoIntra, aims at developing novel multitasking nanoparticles as advanced tools for highly localized and ultrasensitive intracellular imaging and biosensing. These nanoprobes should provide new insights in the spatial and temporal processes at play in live cells and therefore reveal part of their mystery. Such functional objects are achieved through the design of a complex architecture which involves quantum dots as bright and stable luminescent markers encapsulated in a protective silica matrix. These nanoparticles are combined with plasmonic nanocrystals, which offer new strategies for their photothermally induced intracellular delivery. The targeting and imaging of specific subcellular structures is then achieved thanks to proper surface functionalization of the nanoparticles. In addition, the plasmonic nanocrystals also allow these nanoparticles to be used as Surface Enhanced Raman Scattering (SERS) biosensors. Finally, for a higher control on the use of such nano-biosensors, optical tweezers are used to purposefully manipulate and position the nanoparticles inside the cells at the region of interest. Besides their application in cell labeling and biosensing, these functional nanoparticles have tremendous potential applications in the fields of theranostics, nanomedicine and nanobiophotonics, and NanoIntra constitutes a first step toward the development of a full lab-on-a-particle. Thus, through the synthesis and characterization of novel materials and their application to biotechnology, NanoIntra is a multidisciplinary research and training project at the interface between physics, chemistry and biology.

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