Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MULTraSonicA

Financiado

Cerrado

Multiscale modeling and simulation approaches for biomedical ultrasonic applicat...

Multiscale modeling and simulation approaches for biomedical ultrasonic applications Ultrasound-guided drug and gene delivery (USDG) enables controlled and spatially precise delivery of drugs and macromolecules, encapsulated in microbubbles (MBs) and submicron gas vesicles (GVs), to target areas such as cancer tum... ver más

30/11/2026

NIC

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

KEMIJSKI INSTITUT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-05-28

ERC-2019-ADG: ERC Advanced Grant

I+D

Cerrada hace 5 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

NIC

1.54M€ | Lider

SOCIALWARE

955.25K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

TheraCav Harnessing Cavitation for Therapy 1M€ Cerrado

MRGFUS IN THE BRAIN Focused ultrasound under magnetic resonance guidance for tar... 260K€ Cerrado

INVICTUS IN VItro Cavitation Through UltraSound 150K€ Cerrado

PULTAR Delivery of PULmonary Therapeutics through TARgetted Deliver... 150K€ Cerrado

SONOPHARMAGEN Remote controlling biological systems by sonopharmacology an... 3M€ Cerrado

iGOLDD Commercialising MR HIFU an Image Guided Local Drug Delivery... 150K€ Cerrado

Duración del proyecto: 78 meses Fecha Inicio: 2020-05-28
Fecha Fin: 2026-11-30

Líder del proyecto

KEMIJSKI INSTITUT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Ultrasound-guided drug and gene delivery (USDG) enables controlled and spatially precise delivery of drugs and macromolecules, encapsulated in microbubbles (MBs) and submicron gas vesicles (GVs), to target areas such as cancer tumors. It is a non-invasive, high precision, low toxicity process with drastically reduced drug dosage. These advantages open doors to numerous biomedical applications, from sonothrombolysis to blood–brain barrier opening. However, the progress and deployment of this technology is subject to extensive experimentation and heuristics. The proposal aims to develop a virtual environment to quantify and optimize USDG and in particular the MBs and GVs utilized as drug carriers and contrast agents. Their type and concentration, and interface with ultrasound (US) are critical to the success and efficiency of USDG. State-of-the-art USDG systems operate in a narrow range of empirically-tuned US parameters. This empiricism entails severe risks and limitations for clinical applications and delays the adoption of this potent technology. I propose a computational framework that would allow for controlled testing, data-driven quantification of uncertainties, and a rational optimization of experimental US parameters. The framework will rely on submicron resolution modeling and simulation of cavitating MBs and GVs interacting with US. Limitations of existing models based on continuum theory preclude an accurate description of cavitation, drastically degrading the prediction of drug delivery outcomes. I will develop new, data-informed mesoscopic models of US contrast agents, capturing their rheological and acoustic behavior. Specific interactions of US and agents at a submicron level will be included by harnessing novel multiscale methods that enable seamless propagation of US from the macro to microscopic level. The proposed framework will be integrated with experimental efforts to advance USDG across biomedical applications.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores