Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MULTIMOSSY

Financiado

Cerrado

Multimodal mossy fiber input and its role in information processing in the cereb...

Multimodal mossy fiber input and its role in information processing in the cerebellar granule cell layer Synaptic connectivity within and between neurons in brain networks determines the flow of information, how signals are combined and how they are transformed. However, our understanding of information processing in brain networks r... ver más

31/08/2015

UNIVERSITY COLLEGE...

222K€

Presupuesto del proyecto: 222K€

Líder del proyecto

UNIVERSITY COLLEGE LONDON No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-08-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UNIVERSITY COLLEGE LONDON

221.61K€ | Lider

UNIVERSITY COLLEGE LONDON

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

CereCode Neuronal computations and population dynamics in the Cerebel... 1M€ Cerrado

PID2020-115780GB-I00 DIVERSIDAD CELULAR, SINAPTICA Y FUNCIONAL DE LAS REDES TALAM... 138K€ Cerrado

PRE2019-087483 Propagation of the activity of specific populations of cells... 98K€ Cerrado

SENSORIMOTOR Synaptic Mechanisms of Cortical Sensorimotor Integration 2M€ Cerrado

AttentionCircuits Modulation of neocortical microcircuits for attention 1M€ Cerrado

SENSTRIATUM Sensory Integration in the Striatal Microcircuit 1M€ Cerrado

Líder del proyecto

UNIVERSITY COLLEGE LONDON No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 222K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Synaptic connectivity within and between neurons in brain networks determines the flow of information, how signals are combined and how they are transformed. However, our understanding of information processing in brain networks remains poor. The cerebellar cortex is an attractive model to study network processing because it consist of relatively few, well defined cell types and a relatively simple structure. The cerebellum is involved in motor coordination, and the maintenance of balance. It receives both sensory and motor inputs and integrates this information to perform its function. However, at the cellular level, the specific connectivity of mossy fibres (Mfs; the major input to the cerebellar cortex) and their integration is uncertain. This proposal focuses on Mfs arising from different precerebellar nuclei conveying both sensory information and motor command signals. Mfs contact Golgi cells (GoCs) and granule cells (GCs) in the cerebellar granule cell layer (GCL). However, the connectivity rules, and thus the integration of different Mf inputs onto these cells remain poorly understood. To tackle this question, I propose a multidisciplinary approach based on electrophysiology, optogenetics, 2-photon microscopy and network modelling. I will describe the functional connectivity between Mfs and GoCs and GCs by infecting distinct precerebellar nuclei with Channelrhodopsin (ChR)-expressing adeno-associated viruses to label and activate Mfs. I will measure the synaptic weight and plasticity of these connections. Using variants of ChR activated by distinct wavelengths, I will examine whether individual GoCs and GCs receive multimodal information from distinct nuclei. The results will be included in a detailed 3D network of the GCL and spatio-temporal dynamics and processing by the network will be investigated. This work will provide an important conceptual advance in our understanding of information processing in a major cortical structure in the mammalian brain.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores