Innovating Works

VIVOIMAG

Financiado
Multimodal imaging of the in vivo fate of bone transplants
The main objective of VIVOIMAG is to develop bone implants including a new contrast agent sensitive to enzymatic activity of metaloproteases, which will permit for the first time to follow the integration and cell differentiation... The main objective of VIVOIMAG is to develop bone implants including a new contrast agent sensitive to enzymatic activity of metaloproteases, which will permit for the first time to follow the integration and cell differentiation activity in bone tissue bioreactors in vitro and in grafts in vivo using existing non invasive magnetic resonance imaging techniques. The proposal aims at integrating a magnetically functionalized extracellular matrix material into the bone scaffolds, seeding them with cells, implanting them in animal models and following the fate of the implants in vivo using MRI. The aim is to obtain similar results with the magnetically modified scaffolds as the ones obtained currently but having now endowed the grafts with enzymatic reporting activity that can be monitored noninvasively in the living animal. There are currently no methods to detect in situ and in vivo this enzymatic activity without previously sacrificing the transplanted animals, therefore the successful accomplishment of this project would have huge and prolonged impact in the medical field of tissue regeneration. The VIVOIMAG project brings together a multidisciplinary consortium of specialists in different areas of bone implant research, nanoparticles formulation and characterization, magnetic resonance and scintigraphic imaging, who will join forces in order to propose and assess a novel technique for the evaluation of the progress of bone implants in vivo, which can substitute existing invasive techniques based on biopsies. A well planned exchange program among academic and industrial partners will facilitate knowledge sharing, maximize collaborative work and finally achievement of project objectives. The consortium, being aware of the scientific and social importance of bone tissue engineering, has planned a series of dissemination and training activities, aiming at making project knowledge and outcomes available to the scientific community and society. ver más
31/05/2019
"NCSR ""D"""
473K€
Duración del proyecto: 53 meses Fecha Inicio: 2014-12-04
Fecha Fin: 2019-05-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2019-05-31
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
MSCA-RISE-2014: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)
Cerrada hace 10 años
Presupuesto El presupuesto total del proyecto asciende a 473K€
Líder del proyecto
NATIONAL CENTER FOR SCIENTIFIC RESEARCH DEMOK... No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5