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Multifunctional Composite Silica Nanotubes for Targeted Delivery

Multifunctional nanoparticles hold great promise in targeted therapy as well as other biotechnological fields such as biomolecule sensing and cell separation. The potential of these particles to controllably deliver and accumulate... see more

31/12/2012

75K€

Project Budget: 75K€

Project leader

GAZI UNIVERSITESI No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo FP7 notifico la concesión del proyecto The day 2012-12-31 We do not have the information of the call

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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1 Participantes

0.00€ | Leader

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Project leader

GAZI UNIVERSITESI No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 75K€

participation deadline Sin fecha límite de participación.

Project description Multifunctional nanoparticles hold great promise in targeted therapy as well as other biotechnological fields such as biomolecule sensing and cell separation. The potential of these particles to controllably deliver and accumulate therapeutic and diagnostic agents to target sites in the body make them especially useful platforms for the research in various disease types. Ideal particles for these applications should be easy to synthesize, have minimal size variation and hold efficient functionalities. Combining all these properties in the nanoscale level, however, is a formidable challenge. This project proposes a new class of non-spherical nanoparticles called Multifunctional Composite Silica Nanotubes (MuCoSiNT) for targeted therapeutic delivery applications. MuCoSiNTs will be fabricated by a facile synthesis method that allows absolute control over particle dimensions and functionalities. Moreover, they comprise large inner voids that will be filled with a composite gel matrix for the targeted delivery of imaging and therapeutic agents at high payload capacities. The in vitro cytotoxicities and antitumor activities of these particles will be determined by examining their effect on cellular viabilities and growth inhibition profiles. Finally, MuCoSiNT internalization into the cells and consequent morphological changes will be confirmed using microscopic techniques.

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